KIT receptor

Morrison-Graham, K., and Takahashi, Y. (1993). Steel factor and c-kit receptor from mutants to a growth factor system. BioEssays 15 77-83. 

Huang E, Nocka K, Beier DR, Chu T-Y, Buck J, Lahm H-W, Wellner D, Eeder P, Besmer P, 1990. The hematopoietic growth factor KL Is encoded by the SI locus and is the ligand of c-kit receptor, the gene product of the W locus. Cell 63 225... 

Finally, mouse studies have confirmed the hypothesis that RUNXl mutations are initiating events - but require secondary mutations for acute leukemia induction. A major emphasis of current work is to determine what type of mutations collaborate with RUNXl mutations to induce an acute leukemia. Screening of patient samples have underlined the importance of mutations in receptor tyrosine kinases (RTK) in these leukemia. Interestingly, mutations in the KIT receptor are relative rare in AML, but reach an incidence of circa 45% in AML with CBF mutations, perhaps reflecting high levels of KIT expression... 

Cammenga, J., Horn, S., Bergholz, U., Sommer, G., Besmer, P., Fiedler, W. and Stocking, C. (2005) Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate. Blood 106, 3958-3961. 

Identification of patients who would not have otherwise qualified by virtue of a novel test, as has been the case for the use of imatinib in gastrointestinal stromal tumors that express a mutated KIT receptor, and increased treatment duration and compliance linked to prolongation of survival or efficacy in the adjuvant setting. In the final analysis, a significant clinical benefit can be expected to lead to higher adoption rates. 

Kit/KL mast cell growth factor, stem cell or steel factor Two heterogeneously glycosylated forms. KL-1, KL-2. Role In haemalopoiesis and in the development of cell lineages c-Kit receptor Receptor tyrosine kinase... 

Colombo, M., Horowitz, E.M., Botana, L.M., NfacGlashan, D.W.J., Bochner, B.S., Gillis, S., Zsebo, K.M., Galli, S.J. and Lichtenstein, L.M. (1992). The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. J. Immunol. 149, 599-608. 

Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. 2000. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 96 925-32... 

StrongS,ShaldersK, Carr R, etal. KIT receptor (CD117) expression in Merkel cell carcinoma. Br J Dermatol. 2004 150 384-385. 

Krams M, Parwaresch R, Sipos B, et al. Expression of the c-kit receptor characterizes a subset of neuroblastomas with favorable prognosis. Oncogene. 2004 23 588-595. 

Sever M, Jones TD, Roth LM, etal. Exptession of GDI 17 (c-kit) receptor in dysgerminoma of the ovaty Diagnostic and therapeutic implications. Mod Pathol. 2005 18 1411-1416. 

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