Gastrointestinal stromal tumor

Joensuu, H. et al.. Brief report effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor, N. Engl. J. Med., 344, 1052-1056, 2001. 

Delbaldo, C., Chatelut, E., Re, M., Deroussent, A., Seronie-Vivien, S., Jambu, A., Berthaud, P., Le Cesne, A., Blay, J.-Y. and Vassal, G. (2006) Pharmacokinetic-pharmacodynamic relationships of imatinib and its main metabolite in patients with advanced gastrointestinal stromal tumors. Clinical Cancer Research, 12, 6073-6078. 

NHL, non-Hodgkin s lymphoma AEG, adenocarcinoma of the esophagogastreal junction SCC, squamous cell carcinoma GIST, gastrointestinal stromal tumor. 

Suehara Y, Suehara Y, Kondo T, et al. (2008) Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. Clin Cancer Res 14, 1707-17. 

Identification of patients who would not have otherwise qualified by virtue of a novel test, as has been the case for the use of imatinib in gastrointestinal stromal tumors that express a mutated KIT receptor, and increased treatment duration and compliance linked to prolongation of survival or efficacy in the adjuvant setting. In the final analysis, a significant clinical benefit can be expected to lead to higher adoption rates. 

George, S. (2007) Sunitinib, a multitargeted tyrosine kinase inhibitor, in the management of gastrointestinal stromal tumor. Curr Oncol Rep 9(4), 323-327. 

Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan JA, Dychter SS, Larsen PR, Demetri GD, Alexander EK. Hypothyroidism after suni-tinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med 2006 145 660-4. 

Imatinib is administered orally and is well absorbed it is highly protein-bound in plasma. The drug is metabolized in the liver, and elimination of metabolites occurs mainly in feces via biliary excretion. This agent is approved for use as first-line therapy in chronic phase CML, in blast crisis, and as second-line therapy for chronic phase CML that has progressed on prior interferon- therapy. Imatinib is effective also for treatment of gastrointestinal stromal tumors expressing the c-kit tyrosine kinase. Dosage and toxicities are listed in Table 55-6. 

Gastrointestinal stromal tumor (GIST) Mutation c-KIT c-KIT(tyrosi ne-kinase activity) Imatinib, Dasatinib, Sunitinib... 

Fletcher CD, Berman JJ, Corless C, et al Diagnosis of gastrointestinal stromal tumors A consensus approach. Hum. Pathol. 2003 33 459-465. 

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