Therapeutic Implications

In principle, there are two approaches for reducing the formation of NO by iNOS in in vivo, namely, inhibition of iNOS induction and inhibition of the activity of iNOS, by inhibiting either the enzyme itself or one of its essential cofactors. 

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The H2 Receptor and Its Ligands. The discovery of H2 receptors and antagonists occurred in 1972. This topic, including therapeutic implications, is considered in more detail elsewhere (see GASTROINTESTINAL AGENTS). 

There are now many examples of novel peptide transmitter systems that have been identified through orphan receptor ligand screening and greatly impacted the basic understanding of human physiology. Prime examples for the discovery of novel transmitter with therapeutic implications are the neuropeptides orphaninFQ/... 

Morselli PE, Eranco-Morselli R, Bossi E. 1980. Clinical Pharmacokinetics in Newborns and Infants. Age-related differences and therapeutic implications. Clin Pharmacokinet 5 485-527. 

Harper J, Moses MA (2006) Molecular regulation of tumor angiogenesis mechanisms and therapeutic implications. EXS 96 223-268... 

Harman, D. (1993). Free radical involvement in aging. Pathophysiology and therapeutic implications. Drugs Aging 3, 60-80. 

Gladue RP, Tylaska LA, Brissette WH, et al. CP-481,715 A potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. J Biol Chem 2003 278 40473 f0480. 

Al. Aderka, D., Role of tumor necrosis factor in the pathogenesis of intravascular coagulopathy of sepsis Potential new therapeutic implications, hr. J. Med. Sei. 27,52-60 (1991). 

Henderson J., Carpenter K., Cartwright H., Halliday G. (2000a). Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson s disease clinical and therapeutic implications. Brain 123(7), 1410-21. 

Significantly, orexin/ataxin-3 mice respond to intracerebroventricular injection of orexin-A with increased wakefulness and suppression of REM sleep and cataplexy. This pharmacological reversal indicated that orexin receptors remain functional in the absence of orexin neurons, and that these narcoleptic mice can respond to orexin agonists, a finding with significant therapeutic implications (Mieda et al., 2004b). 

Weinfeld A, Swolin B, Westin J. Acute leukaemia after hydroxyurea therapy in polycythaemia vera and allied disorders prospective study of efficacy and leukae-mogenicity with therapeutic implications. Eur J Haematol 1994 52 134-139. 

Wang, Y.-S., Youngster, S., Grace, M., Bausch, J., Bordens, R., and Wyss, D.F. 2002. Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications. Advanced... 

McGeer, E. and McGeer, P. 1997. Inflammatory cytokines in the CNS - possible role in the pathogenesis of neu-rodegenerative disorders and therapeutic implications. CNS Drugs 7(3), 214-228. 

Although a high degree of homology is evident between insulins from various species, the same is not true for proinsulins, as the C peptide sequence can vary considerably. This has therapeutic implications, as the presence of proinsulin in animal-derived insulin preparations can potentially elicit an immune response in humans. 

Therapeutic implications of HSV-1 versus HSV-2 genital infection Complications... 

The biochemistry and pharmacology of 5-HT receptors have been reviewed [74], therapeutic implications presented [75, 76], and functional classification proposed [77], Recently, the neuroanatomy, physiology and pharmacology of 5-HT, receptors have been reviewed [78]. It is evident that major advances have been made since the Gaddum and Picarelli proposal to subdivide 5-HT receptors into D (dibenzyline sensitive) and M (morphine sensitive) types [79]. Subsequently, the D and M receptors have been identified as 5-HT2 and 5-HT, type, respectively. 

Shimizu, W. (2005) The long QT syndrome therapeutic implications of a genetic diagnosis. Cardiovascular Research, 67, 347-356. 

Agnati, L.F., Ferre, S., Lluis, C., Franco, R. and Fuxe, K. (2003) Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacological Reviews, 55, 509-550. 

Hediger, M.A., Romero, M.F., Peng, J.B., Rolfs, A., Takanaga, H. and Bruford, E.A. (2004) The ABCs of solute carriers physiological, pathological and therapeutic implications of human membrane transport proteins. Pflugers Archiv, 447, 465-468. 

R. C. Moellering, /3-Lactamase Inhibition Therapeutic Implications in infectious Diseases -An Overview , Rev. Infect. Dis. 1991, 13, S723-S726. 

Synder RC, Ray R, Blume S, Miller DM (1991) Mithramycin blocks transcriptional initiation of the c-myc PI and P2 promoters. Biochemistry 30 4290-4297 Szyf M (2003) DNA methylation and cancer therapy. Drug Resist Updat 6(6) 341—353 Szyf M, Pakneshan P, Rabbani SA (2004) DNA demethylation and cancer therapeutic implications. 

Rana, B. K., Shiina, T., and Insel, P. A. (2001) Genetic variations and polymorphisms of G protein-coupled receptors Functional and therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 41, 593-624. 

Tao, Y. X. (2006) Inactivating mutations of G protein-coupled receptors and diseases structure-function insights and therapeutic implications. Pharmacol. Ther. Ill, 949-973. 

PMs exhibit a poorer cerebrovascular function, which might affect drug penetration in the brain, with the consequent therapeutic implications. 

Langa, K.M., Foster, N.L., Larson, E.B. (2004) Mixed dementia emerging concepts and therapeutic implications. JAMA, 292, 2901-2908. 

Friedman SL (2004). Mechanisms of disease Mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 1 98-105. 

RUNXl, Leukemic Stem Cells, and Therapeutic Implications... 

Martelli, A., Nyakern, M., Tabellini, G., Bortul, R., Tazzari, P., Evangelisti, C. and Cocco, L. (2006) Phosphoinositide 3 kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 20, 911-928. 

Neovonen PJ. BioavailabUity of phenytoin dinical pharmacokinetic and therapeutic implications. Clin Pharmacokinet 1979 22 247-53. 

Warden W. Therapeutic implications of the drug lag. Clin Pharmacol Ther 1973 14 1022-34. 

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