Keratopathy

Trifluridine 1% topical agent used for acyclovir-resistant herpes infections for 7-14 days Transient burning or stinging, palpebral edema, superficial punctuate, keratopathy, changes in intraocular pressure... 

Ophthalmic-Transient stinging and burning corneal clouding persistent bullous keratopathy retinal detachment transient ciliary and conjunctival injection ciliary spasm with resultant temporary decrease of visual acuity. 

Ophthalmic - Latanoprost-associated ocular adverse events reported at an incidence of 5% to 15% included the following Blurred vision, burning and stinging, conjunctival hyperemia, foreign body sensation, itching, increased pigmentation of the iris, punctate epithelial keratopathy. 

Ciprofloxacin White crystalline precipitates lid margin crusting crystals/scales foreign body sensation itching conjunctival hyperemia bad taste in mouth corneal staining keratopathy/keratitis allergic reactions lid edema tearing photophobia corneal infiltrates nausea decreased vision. 

Adverse reactions may include mild, transient burning or stinging upon instillation palpebral edema superficial punctate keratopathy epithelial keratopathy ... 

The most frequent adverse reactions to trifluridine administration are transient burning or stinging and palpebral edema. Other adverse reactions include superficial punctate keratopathy, epithelial keratopathy, hypersensitivity, stromal edema, irritation, keratitis sicca, hyperemia, and increased intraocular pressure. 

It is noteworthy that this formulation is different from fluorosilicones. Fluorosili-cones are fluorine-containing silicone oils with a 1.35 g/cm density. Their poor tolerance in animals and men was demonstrated by experimental studies [45,46] ocular hypertonia, keratopathy, early emulsification and severe inflammatory reactions. They cannot therefore be used as a heavy internal tamponade product. 

Allergic reactions, alopecia, chest pain, conjunctivitis, diarrhea, diplopia, dizziness, dry mouth, dyspnea, dyspepsia, eye fatigue, hypertonia, keratoconjunctivitis, keratopathy, kidney pain, lid margin crustingor sticky sensation, nausea, pharyngitis, tearing, urticaria... 

Ocular Acute angle closure, blurred vision, cataracts, keratopathy, pigment deposits Muscarinic Routine eye examinations Every-6-month eye examination for cataracts if treated with quetiapine... 

Acute angle closure and difficulty with accommodation can occur from the anticholinergic effects of antipsychotic agents. In addition, pigment deposits may develop in the cornea and lens. Pigmentary retinopathy has been reported with thioridazine. Keratopathy and corneal edema may occur occasionally during pharmacotherapy with chlorpromazine and fluphenazine... 

Potts AM, Rouse EF, Eiferman RA, et al. 1986. An unusual type of keratopathy observed in polyurethane workers and its reproduction in experimental animals. Am J Ind Med 9(2) 203-213. 

Band-shaped keratopathy is caused by the deposition of calcium salts in the basement membrane of the corneal epithelium and superficial stroma. It is typically a chronic process that develops over a period of months and years, and is associated with chronic corneal or intraocular inflammation. 

Infectious crystalline keratopathy developed in a 73-year-old woman with noninsulin-dependent diabetes... 

Acute-onset calcific band keratopathy has been reported in a woman using topical prednisolone (SEDA-20, 372 75). 

Apel A, Campbell I, Rootman DS. Infectious crystalline keratopathy following trabeculectomy and low-dose topical steroids. Cornea 1995 14(3) 321-3. 

Rao GP, O Brien C, Hicky-Dwyer M, Patterson A. Rapid onset bilateral calcific band keratopathy associated with phosphate-containing steroid eye drops. Eur J Implant Refractive Surg 1995 7 251-2. 

There have been repeated reports of ophthalmic complications from tamoxifen, including irreversible retinopathy with seriously reduced visual acuity, retractile opacities, cystoid macular edema, retinal yellow-white dots, and keratopathy (SEDA-6, 356 SEDA-7, 391 SEDA-16, 466). 

Mansour et al. (2004) carried out a prospective study of 24 consecutive patients with bullous keratopathy, who were not immediate surgical candidates. One drop of honey was applied to the cornea after informed consent had been obtained. Patients were instructed to use topical honey three or four times daily. 

Bullous keratopathy is a major complication of cataract surgery. In the past, penetrating keratoplasty was considered the most effective therapy for the symptomatic stage of the disease. Other surgical options have included conjunctival flaps, enucleation (reserved for blind, painful eyes) and, more recently, deep phototherapeutic keratectomy and amniotic membrane transplantation. Medical therapy of bullous keratopathy using hypertonic saline (Nad 5%) has been of marginal benefit due to its relatively weak osmotic effect. 

Mansour, A.M., Zein, W., Haddad, R., and Khoury, J., Bullous keratopathy treated with honey, Acta Ophthalmol. Scand., 82, 312-313, 2004. 

Kl. Kendall, A. C., Infantile hypercalcaemia with keratopathy and sodium depletion. Brit. Med. J. ii, 682-683 (1957). 

L. Zhou, R. Beuerman, A. P. Chew, S. K. Koh, T. Cafaro, E. Urrets-Zavalia, J. Urrets-Zavalia, S. Li, and H. Serra, Quantitative analysis of IV-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ, J. Proteome Res., 8 (2009) 1992-2003. 

In addition to opacification, additional comeal effects from particulate CN exposure include possible penetration of the comeal stroma, severe scarring and ulceration, and deficits in the comeal reflex (Blain, 2003 Scott, 1995). Penetration of the comeal stroma may lead to stromal edema and later vascularization, resulting in further ocular complications. These may include pseudopterygium, infective keratitis, symblepharon, trophic keratopathy, cataracts. 

Pleyer, U., Sherif, Z., Baatz, H., Hartmann, C. (1999). Delayed mustard gas keratopathy clinical findings and confocal microscopy. Am. J. Ophthalmol. 128 506-7. 

Anaphylactoid keratitis Allergic contact keratitis Irritative or toxic keratitis Phototoxic keratitis Toxic calcific band keratopathy Pseudotrachoma Cumulative deposition Microbial imbalance... 

Exposure keratopathy Elevated intraocular pressure Contralateral amaurosis Respiratory arrest Bradycardia... 

In some patients, especially those over age 50 years, a localized or diffuse desquamation of corneal epithelium becomes evident (figure 6-3). This epithelial reaction usually consists of superficial punctate keratitis and probably results from exposure and tear film instability associated with decreased reflex tearing, infrequent blinking, and increased tear evaporation. The punctate keratopathy is frequently absent immediately after anesthetic instillation but may appear 5 to 30 minutes later (Figure 6-4). 

Ansari H, Garibaldi DC,JunAS.Anaesthetic abuse keratopathy as a manifestation of ocular Munchausen s syndrome. CMn Exp Ophthalmol 2006 34 81-83. 

Pimctate epithelial corneal erosions have occurred in patients using latanoprost. This epithelial keratopathy is sporadic and mild, and the condition may be associated more with the BAC preservative than with the latanoprost itself. 

Pupillary block with secondary angle-closure glaucoma Band keratopathy ... 

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