Corneal clouding

The administration of die antiviral ophthalmics may cause occasional irritation, pain, pruritus, inflammation, or edema of the eyes or lids allergic reactions foreign body sensation photophobia and corneal clouding. 

Two drops of a 10% solution instilled in rabbit eyes caused immediate pain, and the epithelium turned gray within seconds the conjunctivae were hyperemic with moderate discharge and corneas were opaque at 2 days. Corneal clouding gradually, but not completely, cleared with in 6 weeks. 

Ophthalmic - Corneal edema corneal clouding corneal decompensation. 

Ophthalmic-Transient stinging and burning corneal clouding persistent bullous keratopathy retinal detachment transient ciliary and conjunctival injection ciliary spasm with resultant temporary decrease of visual acuity. 

Distinguishing clinical features ofMPS-l include corneal clouding and a particular type of acute angular kyphoscoliosis (combined outward and lateral spinal curvature). 

Homozygotes or compound heterozygotes are characterized by the occurrence of corneal cloudings, which after the third decade become apparent upon physical examination. In addition, patients with classical LCAT deficiency develop renal disease with proteinuria and hematuria, which progresses to terminal renal insufficiency and hemolytic anemia [58,85]. 

Corneal clouding, mental retardation, dwarfing, coarse facial features, upper airway obstruction. 

Wide range of severity. No corneal clouding, but physical deformity and mental retardation is mild to severe. 

Hepatosplenomegaly, skeletal deformity, short stature, corneal clouding, mental deficiency. 

Canine MPS I was discovered in a Plott hound that presented with corneal clouding [10]. Studies by Shull and Neufeld showed that the dogs were deficient in a-l-iduronidase [11], Being null, MPS I dogs are genetically similar to the most severe form of MPS I in humans, but clinically they more closely resemble moderately affected patients. These animals provide a valuable bio-chemical/clinical model for MPS I disease. Since they have no confounding residual enzyme activity, they accumulate GAGs in relevant tissues, and their clinical phenotype closely resembles the human disease. 

Differences in the manufacture of unpreserved lidocaine formulations have been postulated as a cause of transient corneal clouding in patients who were given intraocular unpreserved lidocaine 1% as an adjunct to topical anesthesia (332). Independent analysis of the lidocaine solution associated with corneal clouding found it to be hypotonic and not buffered with bicarbonate compared with the solution that did not cause corneal clouding. 

Acute exposure to high levels of 2-ethoxyethanol results in narcosis, pulmonary edema, and severe liver and kidney damage. Low-level exposure causes conjunctivitis, upper respiratory tract irritation, headache, nausea, and temporary corneal clouding. There are limited human data available in the public domain. 

In homozygous familial hypoalphalipoproteinemia, only traces of HDL cholesterol are found in plasma, and apo A-I is undetectable. These patients have corneal clouding and are at increased risk for development of premature CHD. Heterozygotes exhibit no clinical signs but have about... 

Ilq23-q24 1.87 APOA1 Apolipoprotein A-I 107680 Amyloidosis, combined ApoA-I and apoC-III deficiency, corneal clouding, hypoalphalipoproteinemia, Tangier disease, systemic non-neuropathic amyloidosis... 

MPS IH Hurler Corneal clouding, dysostosis multiplex, organomegaly, heart disease, mental retardation, death in childhood a-L-Iduronidase Dermatan sulfate, heparan sulfate... 

MPS IV A Morquio A Distinctive skeletal abnormalities, corneal clouding, odontoid hypoplasia milder forms known to exist Galactose 6-sulfatase Keratan sulfate, chondroitin 6-sulfate... 

MPS VI Maroteaux-Lamy Dysostosis multiplex, corneal clouding, normal intelligence survival to teens in severe form milder forms known to exist V-Acetylgalactosamine 4-sulfatase (arylsulfatase B) Dermatan sulfate... 

Morquio s syndrome is an inherited disorder of glycosaminoglycan catabolism characterized by marked skeletal deformities, corneal clouding, normal intellect, and excessive urinary excretion of heparan sulfate. Matalon et... 

Idoxuridine (1 drop into infected eye/hr during the day and q. 2 hours at night) is indicated in the treatment of herpes simplex keratitis. By altering normal DNA synthesis, idoxuridine inhibits the reproduction of herpes simplex virus. IDU replaces thymidine in the enzymatic step of viral replication, produces faulty DNA, and hence a structure that loses its ability to infect and destroy ocular tissue. Corticosteroids can accelerate the spread of a viral infection and are usually contraindicated in herpes simplex epithelial infections. Idoxuridine occasionally causes irritation, pain, pruritus, inflammation or edema of the eyes or lids and allergic reactions, photophobia, corneal clouding, stippling, and punctate defects in the corneal epithelium. The punctate defects may be a manifestation of the infection, as healing usually takes place without interruption of therapy. 

Individuals who sustain acute ocular injury due to high-dose mustard exposure may experience difficulties even after the initial effects of the injury have subsided.109 112 Recurrent or persistent corneal ulceration can occur after latent periods of 10 to 25 years. This delayed keratopathy111113 may be accompanied by chronic conjunctivitis and corneal clouding. Anecdotal accounts suggest that low-dose exposure also causes increased sensitivity to later exposures to mustard,114 although the existence of increased sensitivity is difficult to substantiate with available scientific evidence.6 About 10% of those with eye injury in World War I had severely affected eyes, with both the cornea and the conjunctiva be-... 

D2. Danes, B. S., Corneal clouding in the genetic mucopol ccharidoses A cell culture study. Clin. Genet. 4, 1-7 (1973). 

Eye Contact Formaldehyde solutions splashed in the eye can cause injuries ranging from transient discomfort to severe, permanent corneal clouding and loss of vision. The severity of the effect depends on the concentration of formaldehyde in the solution and whether or not the eyes are flushed with water immediately after the accident. 

What is referred to as the Hurler-Scheie compound disorder is a clinical phenotype intermediate between Hurler syndrome and Scheie syndrome. Onset of the disorder occurs about 3 years of age. Growth is delayed. Intelligence is normal. Corneal clouding and deafness become debilitating. 

Hunter syndrome is associated with a milder phenotype than that of Hurler syndrome. While there is no corneal clouding as seen in Hurler syndrome, there can be mild retinal degeneration. A gibbus may be present. Developmental delay occurs in the severe type. The hallmark of Hunter syndrome is skin changes. The scapulae contain pebbly, white in color, patches... 

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