Transplantation amniotic membrane

More severe burns typically require extensive medical and surgical treatment. Ascorbate and citrate have been shown to reduce the risk of corneal ulceration and perforation.The use of topical sodium citrate 10% and topical sodium ascorbate 10% every 2 hours and oral vitamin C (500 mg) every 6 hours has been recommended fc>r grades n, HI, and IV burns. Oral tetracyclines have also been shown to reduce collagenase activity, decreasing corneal ulceration after chemical burns. Doxycycline 100 mg twice daily is recommended for grades n, HI, and IV chemical burns. Surgical options include conjimctival transplantation, amniotic membrane transplantation, limbal stem cell transplantation, and lamellar keratoplasty. [Pg.511]

In the last decade, several investigations were performed with regard to in vitro reconstruction of corneal epithelium for transplantation. Meanwhile, many studies have also been reported, dealing with the cultivation and transplantation of corneal epithelium grown on amniotic membranes (i.e., the innermost membrane of the placenta), fibrin gels, or temperature-responsive culture dishes [83-85], However, none of these models has been examined for suitability as a model for drug absorption studies. [Pg.298]

D. Amniotic membrane transplantation with or without lim-bal aUogratfs for comeal surface reconstmction in patients with Umbal stem cell deficiency. Arch Ophthalmol 116(4), 431 41 (1998)... [Pg.75]

The transplantation of amniotic membrane does not suffice for the treatment of a severe LSC deficiency due to a bum [37]. In such a case, it needs to be associated with an LSC transplantation. The amniotic membrane is first sutured to the deepithelialized cornea and the limbal graft is set astride the edge of the amniotic membrane [38]. The cicatrization of the comeal epithelium is completed for 75-100% cases within 3 weeks when the LSC deficit is incomplete and for 70% cases when the deficit is complete [39, 40]. [Pg.106]

Solomon, A., Pires, R.T., Tseng, S.C. Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia. Ophthalmology 108, 449-460 (2001)... [Pg.111]

Tseng, S.C., Di Pascuale, M.A., Liu, D.T, Gao, Y.Y., Baradaran-Raffi, A. Intraoperative mitomycin C and amniotic membrane transplantation for fornix reconstruction in severe cicatricial ocular surface diseases. Ophthalmology 112, 896-903 (2005)... [Pg.111]

Meller, D., Pires, R.T., Mack, R.J., et ah Amniotic membrane transplantation for acute chemical or thermal bums. Ophthalmology 107, 980-990 (2000)... [Pg.111]

Ucakhan, 0.0., Koklu, G., Firat, E. Nonpreserved human amniotic membrane transplantation in acute and chronic chemical eye injuries. Cornea 21, 169-172 (2002)... [Pg.111]

Hanada, K., Shimazaki, J., Shimurra, S., et ah Multilayered amniotic membrane transplantation for severe ulceration of the cornea and sclera. Am J Ophthalmol 131, 324-3311 (2001)... [Pg.111]

Stoiber, J., Muss, W.H., Pohla-Gubo, G., Ruckhofer, J., Grabner, G. Histopathology of human corneas after amniotic membrane and limbal stem cell transplantation for severe chemical burn. Cornea 21, 482-489 (2002)... [Pg.111]

Shimazaki, J., Yang, H.Y., Tsubota, K. Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns. Ophthalmology 104, 2068-2076 (1997)... [Pg.111]

Gomes, J.A., Dos Santos, M.S., Cunha, M.C., Mascaro, V.L., Barros, J.N., De Sousa, L.B. Amniotic membrane transplantation for partial and total limbal stem cell deficiency secondary to chemical bum. Ophthalmology 110, 466-473 (2003)... [Pg.112]

Shimazaki, J., Aiba, M., Goto, E., Kato, N., Shimmura, S., Tsubota, K. Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders. Ophthalmology 109, 1285-1290 (2002)... [Pg.112]

Bullous keratopathy is a major complication of cataract surgery. In the past, penetrating keratoplasty was considered the most effective therapy for the symptomatic stage of the disease. Other surgical options have included conjunctival flaps, enucleation (reserved for blind, painful eyes) and, more recently, deep phototherapeutic keratectomy and amniotic membrane transplantation. Medical therapy of bullous keratopathy using hypertonic saline (Nad 5%) has been of marginal benefit due to its relatively weak osmotic effect. [Pg.408]

When the calcium plaque is thick, it can be removed by scraping with a scalpel or by performing a superficial keratectomy. Other reported methods include the use of a diamond burr, neodymium-yttrium aluminum garnet (Nd YAG) laser, lamellar keratoplasty, and PTK. A recent treatment option described the combined use of superficial lamellar keratectomy, NaEDTA chelation, and amni-otic membrane transplantation. In this procedure the calcific lesions were treated with NaEDTA and a blunt superficial lamellar keratectomy was performed. Once a smooth ocular surface was achieved, an amniotic membrane was transplanted to replace the excised epithelium and stroma. The procedure resulted in the... [Pg.495]

John T. Human amniotic membrane transplantation past, present, and future. Ophthalmol Clin NAm 2003 16 43-65. [Pg.170]

Mermet L Pettier N, SainthiUier JM, Malugani C, Cairey-Remonnay S, Maddens S, et al. Use of amniotic membrane transplantation in the treatment of venous leg ulcers. Wound Repair Regen Jul-Aug 2007 15(4) 459-64. [Pg.171]

Lee SH, Tseng S. Amniotic membrane transplantation for persistent epithelial defects with ulceration. Am J Ophthalmol March 1997 123(3) 303-12. [Pg.171]

Kim JC, Tseng SC. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 1995 14(5). [Pg.172]

Seitz B, Resch MD, et al. Histopathology and ultrastructure of human corneas after amniotic membrane transplantation. Arch Ophthalmol 2006 124(10) 1487-90. [Pg.172]

Arora R, Mehta D, Jain V. Amniotic membrane transplantation in acute chemical bums. Eye March 2005 19(3) 273-8. [Pg.172]

Shay E, et al. Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis. Surv Ophthalmol Nov-Dec 2009 686-96. [Pg.172]

Cargnoni A, Di Marcello M, et al. Amniotic membrane patching promotes ischemic rat heart repair. Cell Transplant 2009 18 1147-59. [Pg.173]

Hopkinson A, McIntosh RS, et al. Proteomic analysis of amniotic membrane prepared for human transplantation characterization of proteins and clinical implications. J Proteome Res 2006 5(9) 2226-35. [Pg.176]

Tseng, S.C., Prabhasawat, P Lee, S.H. Amniotic membrane transplantation for conjunctival sinface reconstrac-tion. Am J Ophthalmol 124, 765-774 (1997)... [Pg.111]

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