Irritancy injection site

Injection-site irritation Injection-site pain (< 1%)... 

Other adverse reactions associated with penicillin are hematopoietic changes such as anemia, thrombocytopenia (low platelet count), leukopenia (low white blood cell count), and bone marrow depression. When penicillin is given orally, glossitis (inflammation of the tongue), stomatitis (inflammation of die mouth), dry mouth, gastritis, nausea, vomiting, and abdominal pain occur. When penicillin is given intramuscularly (IM), there may be pain at die injection site Irritation of the vein and phlebitis (inflammation of a vein) may occur witii intravenous (IV) administration. 

Other—physical dependence, pain at injection site, and local tissue irritation... 

Iron salts occasionally cause gastrointestinal irritation, nausea, vomiting, constipation, diarrhea, headache, backache, and allergic reactions. The stools usually appear darker (black). Iron dextran is given by the parenteral route Hypersensitivity reactions, including fatal anaphylactic reactions, have been reported with the use of this form of iron. Additional adverse reactions include soreness, inflammation, and sterile abscesses at the intramuscular (IM) injection site Intravenous (IV) administration may result in phlebitis at the injection site When iron is administered via the IM route, a brownish discoloration of tlie skin may occur. Fhtients with rheumatoid arthritis may experience an acute exacerbation of joint pain, and swelling may occur when iron dextran is administered. 

The adverse reactions associated with the menotropins include ovarian enlargement, hemoperitoneum (blood in the peritoneal cavity), abdominal discomfort, and febrile reactions. Urofollitropin administration may result in mild to moderate ovarian enlargement, abdominal discomfort, nausea, vomiting, breast tenderness, and irritation at the injection site Multiple births and birth defects have been reported with the use of both menotropins and urofollitropin. 

Local—pain at injection site, sterile abscess, redness and irritation at the application site with transdermal system... 

Rare minor local reactions such as local tenderness, pain at injection site, decreased appetite, irritability, drowsiness, malaise, nausea, diarrhea, fever... 

Adults fever injection site complaints of soreness, erythema, swelling, induration and numbness, varicellalike rash upper respiratory illness headache fatigue cough myalgia disturbed sleep nausea diarrhea stiff neck irritability nervousness constipation... 

General interventions, such as increasing the fluids in the diet, allowing for adequate rest, and keeping the atmosphere quiet and nonstimulating, may be beneficial. The primary health care provider may prescribe acetaminophen, every 4 hours, to control these reactions. Local irritation at the injection site may be treated with warm or cool compresses, depending on the patient s preference. A lump may be palpated at the injection site after a diphtheria, pertussis, tetanus (DPT) injection or other immunization. This is not abnormal and will resolve itself within several days to several months. 

The most frequent adverse effects are local reactions at the injection site (pain, tenderness, erythema, swelling, and pruritus), fevers (greater than 37.5°C or 99.5°F), headaches, dizziness, and irritability. Anaphylaxis and hypersensitivity reactions have been reported rarely and occur within a few hours after vaccine administration. In rare instances, a serum sickness-like apparent hypersensitivity syndrome (arthralgia, urticaria, ecchymoses, erythema multiforme, and erythema nodosum) has been... 

Parenteral iron anaphylaxis (test dose required for iron dextran and observe for 1 hour after), injection-site pain/ irritation, arthralgias, myalgias, flushing, malaise, and fever... 

The most common bisphosphonate adverse effects are nausea, abdominal pain, and dyspepsia. Esophageal, gastric, or duodenal irritation, perforation, ulceration, or bleeding may occur when administration directions are not followed or when bisphosphonates are prescribed for patients with contraindications. The most common adverse effects of IV bisphosphonates include fever, flu-like symptoms, and local injection-site reactions. Osteonecrosis of the jaw occurs rarely if it develops, oral chlorhexidine washes, systemic antibiotics, and systemic analgesics are used based on severity. 

Side effects of the vaccines are soreness at the injection site, headache, fatigue, irritability, and fever. 

Earlier CCR5 clinical compounds included an injectable quarternary salt TAK-779 [31], which was discontinued due to irritation around the injection site, and TAK-220 [32-34], Figure 5 (clinical status unknown). 

Subcutaneous irritation is evaluated as follows Rabbits are euthanized by a lethal dose of barbiturate approximately 24 and 72 h after dosing. The subcutaneous injection sites are exposed by dissection, and the reaction is scored for irritation on a scale of 0 to 5 as follows (Shintani et al., 1967 USP, 1995a) ... 

Judicious selection of excipients for parenteral dosage forms is critical due to their systemic administration.106107 Excipients of a parenteral dosage form may have a significant effect on product safety including injection site irritation or pain. Permissible excipients for parenteral dosage forms are far less than those for oral dosage forms. 

Interferon beta, which is indicated for multiple sclerosis, is administered parenterally only. The most common side-effects are irritation at the injection site and influenza-like symptoms, such as fever, myalgia, chills and malaise. The side-effects tend to decrease with time. 

Local Mild local irritation (eg, injection-site bleeding, rash, pruritus) may occur following subcutaneous injection. 

Initial dose 5 mg/day for 2 weeks increase in increments of 2.5W mg/day every 2 weeks up to 15 mg/day. Therapy may be held at this level for 6 to 9 months or until breakthrough bleeding demands temporary termination. PROGESTERONE For IM use. The drug is irritating at the injection site. 

Pain on injection To minimize the likelihood of pain or inflammation at the injection site, administer flumazenil through a freely flowing IV infusion into a large vein. Local irritation may occur following extravasation into perivascular tissues. 

Dry mouth, nose, and throat that maybe severe decreased sweating, constipation, irritation at subcutaneous or IM injection site Occasional... 

IM, Subcutaneous (10%) Nausea (may occur 30 min after injection, usually diminishes with continued therapy), inflammation at injection site Nasal (12%-i0%) Rhinitis, nasal irritation, redness, sores Occasional... 

Blurred vision photophobia urinary hesitancy somnolence (with high dosage) agitation, excitement, confusion, or somnolence noted (even with low dosages) transient light-headedness (with IM route), irritation at injection site (with IM route) Rare... 

Confusion, arrhythmias, tremors, urine retention, abdominal pain, dry mouth, headache, irritation at injection site, euphoria, dysphoria Rare... 

Pigmentation of skin, mucous membranes, itching in rectal or genital area, sore mouth ortongue, increased BUN, irritation at injection site... 

Alopecia, nausea, insomnia, anorexia, dizziness, diarrhea, abdominal pain, flu-like symptoms, psychiatric reactions (depression, irritability, anxiety), injection site reaction... 

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