Fibrinogen receptors integrin family

The fibrinogen receptor represents the best characterised member of the in-tegrin family of cell adhesion receptors, which are involved in a wide variety of cell-cell and cell-extracellular matrix interactions (reviewed in detail elsewhere) [14,26-29], The integrins consist of non-covalently associated transmembrane a and [i subunits [27], and are commonly grouped into classes defined by shared fi subunits over twenty receptors in eight classes are now known [26], Using the at fi nomenclature, the fibrinogen receptor is now... 

CDllb member of integrin receptor family also called integrin alpha M, Mac-1. Mediates adhesion to substrates by opsonization with iC3b and subsequent phagocytosis, neutrophil aggregation, and chemotaxis. Ligands include fibrinogen. 

CDllc member of b2 of integrin receptor family also called integrin alpha X, CR4, LeuM5. Clears opsonized par deles and immune complexes also binds to fibrinogen and is involved in adhesion of monocytes and neutrophils to endothelium. Myeloid cell marker. 

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