Integrins beta 3 family

Integrins themselves are found on nearly all cells and mediate several physiological responses, such as cell-cell and cell-matrix interactions. Three families of integrins, each family with a common beta subunit in combination with distinct alpha subunits, have been recognized. The beta 1 family, also called very late lymphocyte-activation antigen or VLA, has receptors mediating extracellular matrix interactions with molecules such as collagen, laminin, and fibronectin. Naturally, platelets contain many of the receptors of the beta 1 family. 

Vaddi K, Newton RC. Regulation of monocyte integrin expression by beta-family chemokines. J Immunol 1994 153 4721-4732. 

Thus, while glycoprotein Ia/IIa (a2Pj) binds to collagen, glycoprotein Ic/IIa (a ) binds to fibronectin (5). The other integrin belonging to the beta 1 family that is involved in platelet adhesion is ct6P, which binds laminin. 

The most abundant member of the platelet beta 3 integrin family is also... 

Spring, F. A., Parsons, S. F., Ortlepp, S., et al. Intercellular adhesion molecule-4 binds alpha 4 beta 1 and alpha V-family integrins through novel integrin-binding mechanisms. Blood 98 458-466, 2001. 

Galvete, J. J., Henschen, A., and Gonzalez-Rodriguez, J. (1991). Assignment of disulphide bonds in human platelet GPllla. A disulphide pattern for the beta-subunits of the integrin family. Biochem. J. 274, 63-71. 

Shakoori AR. Phosphorylation and glycosylation interplay Protein modifications at hydroxy amino acids and prediction of signaling functions of the human beta(3) integrin family. J. Cell Biochem. 2006 99 706-718. 41. 

---