Heterodimeric glycoproteins

Integrins. The integrin family has been identified as excellent candidates for the development of target specific cancer therapies.29 Integrins are heterodimeric glycoproteins that consist of a and P subunits, which combine to form the various types of integrins. Currently, 18 a subunits, 8 P subunits, and approximately 22 different integrins have been identified.29,30... 

Integrins are a family of transmembrane heterodimeric glycoproteins that are receptors for specific epitopes of extracellular matrix proteins and for other cell-surface molecules (Kramer et al, 1993). Integrins exist as a dimer complex composed of an a-subunit (120-180 kD) noncovalently associated with a /1-subunit (90-110 kD) (Hynes, 1992). At least 8 /1-subunits and 14 -units have been identified and are concentrated at loci, called focal adhesion sites, of close proximity between cells and extracellular matrices on substrates (Hynes, 1992). Focal adhesion sites are points of aggregation of, and are physically associated with, intracellular cytoskeletal molecules that control, direct, and modulate cell function in response to extracellular signals (Schwartz, 1992). 

Ricin is a heterodimeric glycoprotein (MW = 66 000) produced by the castor bean plant Ricinus communis with the two protein subunits linked by a single disulfide bond. Conditions for the analysis of ricin with CE, using uncoated and coated capillaries as well the influence of buffer systems (run buffer... 

Clusterin is a heterodimeric glycoprotein produced by a wide array of tissues and found in most biological fluids. The proposed physiologic functions of clusterin include complement regulation, lipid transport, sperm maturation, initiation of apoptosis, endocrine secretion, membrane protection, and promotion of cell interactions. 

Diagnostic. Heterodimeric glycoprotein with two noncovalently linked subunits identical to human pituitary TSH. 

The seeds of the ubiquitous castor bean plant (Ricinus communis) contain high concentrations of a highly toxic, relatively stable, heterodimeric, glycoprotein toxin called ricin, which is a type 2 ribosome-inactivating protein (RIP) (Burrows and Tyrl, 2001 Millard and LeClaire, 2008 Salem et al., 2008b). The inhibition of protein synthesis by ricin and related t5q>e 2 RIPs has been associated with endothelial toxicity and, depending on the route of exposure, severe gastrointestinal or respiratory... 

T-cell receptors (TCR) are heterodimeric transmembrane glycoproteins found exclusively in T cells, with extracellular domains that closely resemble antibody Fab structures. Each of the TCR a and p chains forms half of an extracellular antigen-binding domain, and in addition has one transmembrane... 

Integrins are adhesion molecules involved in cell-matrix interaction. Integrins are heterodimeric membrane glycoproteins formed by the combination of an a- and p-subunit with an intracellular and an extracellular domain [115]. In the brain, endothelial cells, astrocytes, and the basal membrane such as laminin and collagen contribute to form the... 

Blobel et al., 1992). However, a recent reevaluation of the N-terminus of mature fertilin a showed clearly that this subunit also contains an intact disintegrin domain (Lum and Blobel, 1997). Thus mature fertilin is a heterodimeric complex of two membrane-anchored glycoproteins that both contain an N-terminal disintegrin domain and therefore most likely interact with an integrin on the egg (Figure 2). 

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