Receptors domain

Foord, S. M., and Marshall, F. H. (1999). RAMPS Accessory proteins for seven transmembrane domain receptors. Trends Pharmacol. Sci. 20 184-187. 

These receptors are unlike the well-characterised rhodopsin-like family in that they have a large extracellular N-terminus and hormone binding seems to be dominated by this domain rather than the transmembrane domains. Receptors in this class include... 

FIGURE 18-10 Serpentine (seven-transmembrane-domain) receptors for peptides have binding for their peptide ligands within the membrane... 

T4-fiber fold Triple /i-helix Collar domain Receptor-binding domain... 

Figure 2. Mechanisms and signalings of neuronal death. Death can be initiated at the membrane by activation of death domain receptors (DDR), or by intracellular signalings through oxidative stress (and the production of reactive oxigen species, ROS), perturbed calcium homeostasis, mitochondrial dysfunction (release of cytochrome c, cytC), activation of caspases, as well as reactivation of cell cycle genes such as the transcription factor E2F (see text). Interconnections have been demonstrated (dotted lines) depending on the apoptotic context...

Type I collagen can interact with various other molecules in the extracellular matrix and on the cell surface. Cell receptors of type I collagen have been identified and include the heterodimeric integrin family receptors, ctl, 0 2, olO, and ol 1, especially o2/3l, the receptor tyrosine kinase discoidin domain receptor (DDR), and the heparan sulfate membrane proteoglycan syndecan family... 

Kinase domain receptor (vascular endothelial growth factor receptor 2)... 

Cao, J., Panetta, R., Yue, S., Steyaert, A., Young-BelKdo, M. and Ahmad, S. (2003) A naive Bayes model to predict coupling between seven transmembrane domain receptors and G-proteins. Bioinformatics 19, 234-240. 

Denecker G, Vercammen D, Declercq W, et al. Ap op to tic and necrotic cell death induced by death domain receptors. Cell Mol Life Sci 2001 58 356-370. 

Various signaling systems used by animal cells also have analogs in the prokaryotes. As the full genomic sequences of more, and more diverse, bacteria become known, researchers have discovered genes that encode proteins similar to protein Ser or Thr kinases, Ras-like proteins regulated by GTP binding, and proteins with SH3 domains. Receptor Tyr kinases have not been detected in bacteria, but (P)-Tyr residues do occur in some bacterial proteins, so there must be an enzyme that phosphorylates Tyr residues. 

Scheme 28. Synthesis of a diphenylmethylamine library targeted to 7-transmembrane domain receptors.

What do SNMPs do The identification of Apo/SNMPl followed photoaffinity labeling studies that tentatively identified a 69 kDa protein as a pheromone receptor (Vogt et al., 1987) however, a role as pheromone receptor seems highly unlikely because SNMPs appear to associate with most olfactory neurons, and are neither 7-transmembrane domain receptors nor show the diversity expected for ORs. SNMPs certainly show no similarity to the presumed ORs identified in D. melangaster, A. gambiaea and H. virescens (Clyne et al., 1999 Vosshall et al., 1999 Hill et al., 2002 Krieger et al., 2002). If SNMPs are not ORs, what are they ... 

It is apparent that these new structured clefts, struts, surfaces and enclosures in the 1-100 nm size range will have important roles as quantum confinement domains, receptors, containers, carriers, catalytic surfaces or scaffolding for molecular recognition in the emerging area of nanotechnology (see Ref. 183). 

Within two years, the receptor (named CBj) was cloned from rat brain by a group at NIH [29], It was shown to belong to the 7 transmembrane domain receptor family, members of which mediate their activity through GTP-binding proteins. 

Tyrosine domain and an intracellular protein kinase domain. Receptor tyrosine kinases... 

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