Reproduction studies

Two Generation Reproduction Study via Inhalation (With A. Neurotoxicology f Pathology Component) in Albino Rats Using Cyclohexanone, a study performed by American Biogenics Corp., Decatur, lU., for The Industrial Health Foundation, Mar. 1986. 

In a three-generation reproduction study with DOSS on rats [76] it was shown that administering DOSS in the diet of three successive generations of rats at levels of 0.5% and 1.0% caused a reduction in body weight for parental males in all generations and for FI and F2 females. However, the reduced body weight did not interfere with development of normal reproductive performance. 

GL22 Safety reproduction Studies to evaluate the safety of residues of veterinary drug in human food reproduction studies... 

EPA (1988a) has discussed the results of two reproductive studies in rats. Results of these studies have not been presented in peer-reviewed scientific journals and are not available to the public. If these data become available, they will provide valuable information on the reproductive hazards of methyl parathion. 

In summary, although the available reproductive studies indicate endosulfan has no adverse effects on reproductive performance in animals, adverse effects on male reproductive organs have been seen in young rats and mice. The lack of effects seen in the studies that examined reproductive performance (specifically fertility rate) in treated males and females seems difficult to explain, given the finding of altered spermatogenesis in the more recent studies. 

FMC. 1965. Three-generahon reproduction study in albino rats on thiodan Results through weaning of Fib litters. Conducted for Food Machinery and Chemical Corporation, Niagara Chemical Division. Industrial Bio-Test Laboratories, Inc., Northbrook, IF. 

Kendall RJ, Brewer LW, Lacher TEJ, Whitten ML, Marden BT. 1989. The use of starling nest boxes for field reproductive studies. Institute of Wildlife Toxicology. EPA/600/ 8789/056. National Technical Information Services publication number PB89 195 028/AS, i-vii + 82 pp. 

Similar results were also observed in a two-generation reproductive study using brown Ranch Wild mink that ingested 0, 16, 45, or 262 mg/kg/day (males) or 0, 20, 57, or 330 mg/kg/day (females) (Bucci et al. 1997). No changes in brain acetylcholinesterase were observed in either the Fj or F2 offspring. 

Bucci TJ, Mercieca MD, Perman V. 1997. Two-generation reproductive study in mink fed DIMP Final report, study No. TP-001. Prepared by Pathology Associates International, Jefferson, AR. 

Harding Lawson Associates. 1992. Offpost operable unit remedial investigation final addendum. Hardisty JF, Pellerin RJ, Biskup RK, et al. 1977. Reproductive studies with... 

Healy CE, Nair RS, Lemen JK, et al. 1991. Subchronic and reproduction studies with dibutyl phenyl phosphate in Sprague-Dawley rats. Fundam Appl Toxicol 16 117-127. 

In a three - generation reproduction study in rats, Beliles et al. (1980) found that exposure of animals to acrylonitrile in drinking water at 70 mg/kg/day resulted in reduced viability and lactation indices in all generations. The authors considered the reduced pup indices to be the result of maternal toxicity, possibly related to reduced milk production due to decreased water intake by the dams. Fostering of pups on untreated dams lessened pup mortality. Measurement of acrylonitrile in the pups was not performed. 

Reproductive Effects. There are no data available on the reproductive effects in humans. However, a three-generation reproduction study in rats showed that acrylonitrile has an effect on reproduction. 

Beliles RP, Paulin HJ, Makris NG, et al. 1980. Three-generation reproduction study of rats receiving acrylonitrile in drinking water. Chemical Manufacturers Association. Washington, DC. LBI Project No. 2660, February. 

Animal reproduction studies have shown an adverse effect on the fetus however, there are no adequate and well-controlled studies in humans, but potential benefits may warrant the use of the drug in pregnant women despite potential risks. 

Murray, F.J., F.A. Smith, K.D. Nitschke, C.G. Humiston, R.J. Kociba, and B.A. Schwetz. 1979. Three-generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol. Appl. Pharmacol. 50 241-252. 

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