Import a file

However, this advance has an important shortcoming the lack of context. More than one idea is expressed in a document a patent on oxidation catalysts, for example, could include examples of the oxidation of methanol to formaldehyde and of 2-propanol to acetone. A simple coordinate search for conversion of methanol to acetone would retrieve such a document from a file that provides no context. 

Pump performance curves are the least used, least consulted, least appreciated, and least understood aspect of the world of industrial pumps. The plant personnel who most need their pump curves, meehanics and operators, generally don t have the curves and accompanying information at their disposal. The people who control the performance curves store them in a file, in a drawer, in a cabinet that s almost never opened. They don t share the information contained in the curves with the people who need it. Maybe it s because they themselves don t understand the information to share it. In the next few paragraphs and pages, we re going to explain the pump performance curves. This might be the most important chapter of the book. 

Nowadays one very often fits data by means of a least-squares computer program. (Indeed, in Chapter 2 some data-fitting applications will be considered.) It is important to examine the residuals from the fits, to confirm that, with time, they lie randomly about the zero line. Examining them makes it is much easier to spot discrepancies. If the kinetic data are acquired with a computer-controlled instrument, then the data are already contained in a file that can be read by the fitting program. 

Chemical spills in the laboratory may be hazardous, damaging to flooring and furniture finishes, or simply messy to clean up. Laboratory equipment houses and distributors of safety equipment carry a variety of clean-up kits made for specific types of spills, depending on the types of chemicals handled. Generally, the kits contain absorbents or neutralizers, or a combination of the two, plus instructions for use. Kits should be stored as close as possible to where spills are likely to occur and not in a remote storeroom. Instructions must be kept with the kits, not in a file cabinet. Quick action in case of a spill is important in reducing both hazards and damage. 

In most cases, the data that you use for clinical trial analyses are found in some kind of computer file external to the SAS System. The data you need may be found in a permanent SAS data set, a relational database table found in Oracle or Microsoft SQL Server, a Microsoft Access or Excel file, a simple delimited ASCII text file, or even an XML file. In any case SAS provides a wide array of ways in which to import data files into SAS. We explore these tools and the advantages and disadvantages of each in this chapter. 

Notice how Delimited File has been selected as a data source. Click Next and use the browse feature to select the file to import. Notice the important Options button under the file selection field, which will open the SAS Import Delimited File Options window. Click the Options button and you will see a window like the following ... 

Click Next, and a file browser window will open that allows for the drill-down and selection of the Microsoft Excel file of interest. Once the file is selected, a Select Table window will open. This window allows you to pick which worksheet in the Excel file you want to turn into a SAS data set. Click the Options button to see the new options available with SAS 9.1 and PROC IMPORT. 

PROC CDISC is a SAS procedure available as a hot fix for SAS 8.2 that ships as part of SAS 9.1.3. PROC CDISC allows you to export (and import) XML files that are compliant with the CDISC ODM version 1.2 schema. Here are a sample PROC CONTENTS and a sample PROC PRINT of a SDTM data set called DM (for demographics) that we will export to ODM using PROC CDISC. 

A file with the complete volume indexes Vols.22 (1972) through 169 (1994) in delimited ASCII format is available for downloading at no charge from the Springer EARN mailbox. Delimited ASCII format can be imported into most databanks. 

It is important to check that a patient presenting with a foot problem does not have diabetes. Diabetic patients are at an increased risk of developing infections because of injury from the keratolytic action of salicylic acid. Patient should be advised to apply petroleum jelly to the skin surrounding the area where salicylic acid will be applied. Petroleum jelly protects the skin from the irritation caused by the salicylic acid. Using a file or pumice stone to gently rub away the surface of the corn or calluses helps to remove them. 

Conducting the Audit A staff person should accompany the auditors at all times so that there can be immediate attention to their needs and so that immediate corrective action can be taken on items the auditors point out. It is important that all staff persons be courteous and cooperative at all times and that all documents be immediately available in the work area. Any other items the auditors request should be provided. A daily debriefing session should be held to assess the progress of the audit. It is important to maintain a log of the activities and to also maintain a file of duplicate copies of all documents given to the auditors. Any proprietary information should be protected. 

Completing the Audit At the conclusion of the audit, an exit interview should be conducted so that all concerns can be immediately conveyed to staff. It is important to be aware of questions or concerns the auditors may have before they leave. A file of inspection documents should be maintained... 

A validation protocol is a document that describes the item to be qualified, the tests and checks to be performed, as well as the results that are expected to be obtained. It is a file in which the records, results, and evaluation of a completed validation program are assembled. It may also contain proposals for the improvement of processes and/or equipment [1]. Validation protocols are important in ensuring that documented evidence is taken which demonstrates that an equipment item, a system, a process, or a method consistently performs at a specified level... 

The responsibility for providing information about packaging components rests foremost with the applicant of an NDA, ANDA, or BLA, or with the sponsor of an IND. This information may be provided to the applicant by the manufacturer of a packaging component or material of construction and may be included directly in the application. Any information that a manufacturer does not wish to share with the applicant or sponsor (i.e., because it is considered proprietary) may be placed in a Type III DMF and incorporated into the application by a letter from the manufacturer to the applicant that authorizes reference to the DMF. The letter of authorization should specify the firm to whom authorization is granted, the component or material of construction being described, and where the information or data is located in the file by page number or date of submission. This last item is especially important for files that contain information on multiple components or have several volumes. Information in a Type III DMF is not restricted to data of a proprietary nature. DMF holders may include in their files as much or as little information as they choose. In addition, a manufacturer of a packaging component is not required to maintain a Type III DMF. Without a DMF, there is no procedure for the FDA to review proprietary information except by submission to the application. 

This draws us to an important conclusion To use time wisely, create and use a filing system. The old proverb puts this in more memorable terms ... 

It 1s the single most Important reference for addressing common questions that arise during the study. As a working document, 1t 1s necessary that multiple copies be available for use by members of the study team. Once the document 1s finalized with all the appropriate signatures, 1t 1s Important that 1t not be relegated to a file where 1t 1s not readily available when needed. 

Of course price and convenience can be a very important factor in the choice of a program to calculate log Poct. Availability on one s computer — e.g. UNIX workstation, VAX station, or the popular desktops, Macintosh or Windows for P.C. — can be the deciding factor. The ability to import structural files in a format that can be handled in batch mode may be a critical need for some. Entry by either name or CAS number might be necessary to others. Providing pKas or tautomeric forms may be very attractive to still others. The manner in which structures are displayed may be a factor. 

Pharmacophore profiles are defined that represent the set of all the pharmacophores found across the conformers of a series of conformers or series of molecules. Each pharmacophore added to the profile has to be unique. This profile will help in showing the spread of pharmacophores across the conformational space of a molecule or a series of molecules. No sum of the exhibited pharmacophores or normalization is done. There is no direct graphical representation of pharmacophore models. The pharmacophores can be saved to a file in CSV format that can be imported into a MySQL or Oracle database. This approach permits the use of standard SQL queries to extract common pharma-... 

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