Immunoglobulin-E

Type I allergies are mediated by immunoglobulin E (IgE). Unlike the other immunoglobulins (G,M,A, and D), which are part of the essential defense... 

Atopy is the propensity to develop allergic reactions mediated by immunoglobulin E. 

Type I allergic reactions are inappropriate immune responses to an allergen with preferential synthesis of immunoglobulin E (IgE), a special antibody class, which binds to mast cells and basophilic granulocytes via Fee receptors. Binding of the allergen to the cell-bound IgE initiates the rapid release of allergic mediators, most prominently histamine, and the de novo synthesis of arachidonic acid metabolites and cytokines, which are responsible for the clinical symptoms. 

Shim JY, Kim BS, Cho SH, Min KU, Hong SJ Allergen-specific conventional immunotherapy decreases immunoglobulin E-mediated basophil histamine releasability. Clin Exp Allergy 2003 33 52-57. 

Finbloom DS, Metzger H Binding of immunoglobulin E to the receptor on rat peritoneal macrophages. J Immunol 1982 129 2004-2008. 

Persson GB, Chung KF, Bousquet J. Kerstjens HA, Fox H, Thirlwell J, Cioppa GD Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy 2004 34 632-638. 

Bansal G, Xie Z, Rao S, Nocka KH, Druey KM Sup- 54 pression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13. 

Ebo DG, Venemalm L, Bridts CH, Degerbeck F, Hagberg H, De Clerck LS, Stevens WJ Immunoglobulin E antibodies to rocuronium a new diagnostic tool. Anesthesiology 2007 107 253. 

In allergic rhinitis, the normal mechanisms by which the nasal mucosa humidifies and filters inspired air are disrupted due to an immunoglobulin E (IgE)-mediated immunologic reaction. 

American Academy of Pediatrics allergen immunotherapy allergic rhinitis central nervous system histamine-1 receptor antagonist immunoglobulin E over the counter perennial allergic rhinitis seasonal allergic rhinitis... 

Price KS, Friend DS, Mellor EA, De Jesus N, Watts GF, Boyce JA. CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13. Am J Respir Cell Mol Biol 2003 28(4) 420-427. 

Asthma is characterized by variable symptoms such as wheeze, shortness of breath and coughing and is usually associated with airway inflammation, with variably reduced spirometric indices [4, 5], with increased non-specific airway responsiveness (AR) to spasmogens [6, 7] and increased levels of semm immunoglobulin E (IgE) and eosinophils [8-10]. The symptoms of asthma are primarily due to excessive airway narrowing, which leads to an increased resistance to airflow, especially during forced expiration, and produces characteristic spirometric findings. A cardinal feature of asthma is that airway narrowing is reversible either spontaneously or as the result of therapy. 

These are allergies where immunoglobulin E antibodies can be detected. These allergies tend to be rapid in onset with a time from consumption to symptoms ranging from minutes to a few hours. 

The answers are 25-e, 26-b, 27-a. (Hardmanr pp 67—68. Katzung, pp 30, 134.) Anaphylaxis refers to an acute hypersensitivity reaction that appears to be mediated primarily by immunoglobulin E (IgE). Specific antigens can interact with these antibodies and cause sensitized mast cells to release vasoactive substances, such as histamine. Anaphylaxis to penicillin is one of the best-known examples the drug of choice to relieve the symptoms is epinephrine. 

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