Anti-immunoglobulin E

Persson GB, Chung KF, Bousquet J. Kerstjens HA, Fox H, Thirlwell J, Cioppa GD Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin Exp Allergy 2004 34 632-638. 

Racine-Poon, A., Botta, L., Chang, T., Davis, F., Gygax, D., Liou, R., Ro-hane, P., Staehelin, T., VanSteijn, A., and Frank, W., Efficacy, pharmacodynamics, and pharmacokinetics of CGP 51901, an anti-immunoglobulin E chimeric monoclonal antibody, in patients with seasonal allergic rhinitis, Clinical Pharmacology and Therapeutics, Vol. 62, No. 6, 1997, pp. 675-690. 

Ayres JG, Higgins B, Chilvers ER, Ayre G, Blogg M, Fox H. Efficacy and tolerability of anti-immunoglobulin E therapy with Oma-lizumab in patients with poorly controlled (moderate-to-severe) 50. allergic asthma. Allergy 2004 23 76-81. 

Milgrom H, Berger W, Nayak A, Gupta N, Pollard S, McAlary M, Taylor AF, Rohane P. Treatment of childhood asthma with anti-immunoglobulin E antibody (omalizumab). Pediatrics 2001 108(2) E36. 

Fig. 14.6. Diffusion-in-gel EIA. The bottom of a Petri dish is coated with antigen (A), overlayered with agarose (B), and antibodies are allowed to diffuse from a well punched in the agarose (C, D). The agarose is removed and antibody is detected with enzyme-labeled anti-immunoglobulin (E). Substrate is added in hot agarose and the diameter of the stained zone (F) is measured and plotted in a standard curve against the antibody concentration.

Owen CE. Anti-immunoglobulin E therapy for asthma. Pulm Pharmacol Ther 2002 15 417-424. 

The specific binding of [ I]-protein A to the Fc region of rabbit immunoglobulin G anti-immunoglobulin E, has been used in the determination of specific anti-immunoglobulin E antibody bound to immobilized immunoglobulin E. ... 

Respiratory Xolair First anti-immunoglobulin E (IgE) for asthma and rhinitis Novartis, Genentech, Tanox Inc. Leading... 

ANAb Anti-nuclear antibodies ANCA Anti-neutrophil cytoplasmic auto antibodies cANCA Cytoplasmic ANCA pANCA Perinuclear ANCA AND Anaphylactic degranulation ANF Atrial natriuretic factor ANP Atrial natriuretic peptide Anti-I-A, Anti-I-E Antibody against class II MHC molecule encoded by I-A locus, I-E locus, anti-lg Antibody against an immunoglobulin... 

Thefluorochromes and dyes presented here are unconjugated. They maybe conjugated to immunoglobulins (e.g., anti-CD3 ... 

Engvall, E. and Perlman, P. (1972) Enzyme-linked immunosorbant assay, ELISA. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. J. Immunol. 109,129. 

Anti-anaphylactic activity. Water extract of the dried fruit, at a concentration of 1 pg/ mL, produced weak activity on the rat Leuk-RBL 2H3 vs biotinyl immunoglobulin E-avidin complex-induced degranulation of (3-hexosaminidase 5 Anti-androgenic effect. Ethanol (95%) extract of the aerial parts, administered intraperitoneally to castrated mice at a dose of 2 mg/animal, produced strong activity The dried leaf, smoked by 13 male adults for 21 days, was inactive . 

IgG prepared from an anti-immunoglobulin serum, e g., rabbit antihuman IgG serum, or murine antihuman IgG MAb for the purification of human IgG (see Note 17)... 

Immunoblotting techniques involve the identification of a protein target via antigen-antibody-specific reactions. Proteins are typically separated by electrophoresis in polyacrylamide gels, and then transferred ( blotted ) onto chemically resilient membranes (e.g., nitrocellulose, polyvinylidene difluoride) where they bind in the pattern they took in the gel. The membrane is overlaid with a primary antibody directed to the specific target, then with a secondary antibody (anti-immunoglobulin) labeled with radioisotopes, enzymes or other marker compounds. 

Baudouin V, Crusiaux A, Haddad E, Schandene L, Goldman M, Loirat C, Abramowicz D. Anaphylactic shock caused by immunoglobulin E sensitization after retreatment with the chimeric anti-interleukin-2 receptor monoclonal antibody basiliximab. Transplantation 2003 76(3) 459-63. 

ZEISS, C.R., KANELLAKES, T.M., BELLONE, J.D., LEVITZ, D PRUZANSKY, JJ. PATTERSON, R. (1980) Immunoglobulin E-mediated asthma and hypersensitivity pneumonitis with precipitating anti-hapten antibodies due to diphenylmethane diisocyanate (MDI) exposure. Journal of Allergy and Clinical Immunology, 65, 346-352. 

The results of studies in humans on the immune reaction to elemental mercury vapor exposure have been inconsistent, with either increases or decreases in immune activity. In workers exposed occupationally to mercury vapor, a stimulation of T-lymphocytes, manifested by an increased number of T cells, T-helper cells and T-suppressor cells, was observed (Moszczynski et al. 1995). Further, a reduction in the number of B lymphocytes as of CD4+ lymphocytes in T cells was found in mercury vapor-exposed workers and, on the other hand, increased immunoglobulin E levels (Dantas and Queiroz 1997). Renal biopsies of two mercury-exposed workers who had developed proteinuria revealed deposits if IgG and complement C3 in the glomeruli (Tubbs et al. 1982). High anti-DNA antibody titers have been reported... 

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