Immune human

Marks, J. D., Hoogenboom, H. R., Bonnert, T. P., McCafferty, J., Griffiths, D., and Winter, G. (1991). By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222, 581-597. 

The synthesis of IgG in African subjects unprotected from malaria was approximately twice (169 mg/kg/day) that of Africans protected from malaria and seven times that of Caucasians (23 mg/kg/day), implying that malaria must account for a good proportion of the high immunoglobulin levels found in persons in a malarious area (C18). In fact absorption experiments have shown that about 3-10% of the immune human IgG was specific malarial antibody (C25). 

Tetanus immune globnlin (hnman) [USAN] Tetanus immune human globuhn [former USAN]... 

De Haardt, H. J., van Neer, N., Reurst, A., Hufton, S. E., Roovers, R. C., Henderikx, P., et al. (1999) A large non-immunized human fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies. J. Biol. Chem. 274, 18,218-18,230. 

Human lactoferrin (HL) is a component of innate immunity. Human lactoferrin is an iron-binding protein found in milk, granulocytes and exocrine secretions. It is released during inflammation, has bactericidal effects and reduces cytokine production by binding to the lipid A portion of endotoxin (Appelmelk et al., 1994). 

This discussion has focused on the desire to create a one-pot naive phage antibody library. However, phage display has also been used very effectively to isolate binding antibodies when libraries are made from immunized experimental animals [32], or from naturally immunized humans [7, 30] in these cases the V-gene source being either spleen or peripheral-blood lymphocytes. 

Lang AB, Ftirer E, Senyk G, Larrick JW Cryz SJ Jr (1990a) Systematic generation of antigen specific human monoclonal antibodies with therapeutical activities using active immunization. Human Antibodies and Hybridomas 1 96-103. 

Kemp, D. J., Coppel, R. L., Cowman, A. F., Saint, R. B., Brown, G. V., and Anders, R. F. (1983). Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli Detection with antibodies from immune humans. Proc. Natl. Acad. Sci. USA 80, 3787-3791. 

V-genes from IgM mRNA of B cells of immunized human donors... 

By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J Mol Biol 222(3) 581-597, 1991. 

Rosen, G., Londner, M. V., Sevlever, D. and Greenblatt, C. L. (1988) Leishmania major Glycolipid antigens recognized by immune human sera. Mol. Biochem. Parasitol. IT. 93-100. 

The clostridial neurotoxins are the most toxic substances known to science. The neurotoxin produced from Clostridium tetani (tetanus toxin) is encountered by humans as a result of wounds and remains a serious public health problem in developing countries around the world. However, nearly everyone reared in the western world is protected from tetanus toxin as a result of the ordinary course of childhood immunizations. Humans are usually exposed to the neurotoxins produced by Clostridium botulinum (ie, the botu-linum toxins, of which there are seven in all) by means of food poisoning, although there are rare incidents of wound botulism and a colonizing infection of neonates known as infant botulism.1 Since the incidence of botulinum poisoning by all routes is very rare,... 

CAS 56-12-2 EINECS/ELINCS 200-258-6 Synonyms 4-Aminobutanoic acid y-Aminobutanoic acid 4-Aminobutyric acid 4-Amino-n-butyric acid DL-4-Aminobutyric acid y-Aminobutyric acid y-Amino-n-butyric acid Butanoic acid, 4-amino- Butyric acid, 4-amino- 3-Carboxypropyiamine GABA Giobuiin, immune human serum immugiobin Piperidic acid Piperidinic acid Classification Organic compd. nonprotein amino acid... 

Glidox 500. See 2,6,6-Trimethylbicyclo (3.1.1) heptyl hydroperoxide Gin. See L-Glutamine Globulin, immune human serum. See Aminobutyric acid... 

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