Human tetanus immune globulin

Botulism (adjunctive therapy to antitoxin), gas gangrene and tetanus (adjunctive therapy to human tetanus immune globulin)... 

Penicillin G is the drug of choice for gas gangrene due to Clostridia the dose is 12-20 million units per day given parenterally. Adequate debridement of the infected areas is essential. Antibiotics probably have no effect on the outcome of tetanus. Debridement and administration of human tetanus immune globulin may be indicated. 

Human tetanus immune globulin (TIG), 3000-5000 lU administered IM, will neutralize circulating toxin but has no effect on toxin already fixed to neurons. TIG should be given as early as possible to a patient with suspected tetanus and to persons with a fresh wound but possibly inadequate prior immunization. 

B. Human tetanus immune globulin (antitoxin) provides passive immunity by neutralizing circulating tetanospasmin and unbound toxin in a wound. It does not have an effect on toxin that is already bound to neural tissue, and tetanus antibody does not penetrate the blood-brain barrier. 

B. Antitoxin. The equine tetanus antitoxin is contraindicated in persons who have had previous hypersensitivity or semm sickness reactions to other equine-derived products. Preferabiy, use the human tetanus immune globulin product in all cases, if it is available. 

B. Antitoxin. Human tetanus immune globulin is given at 3000-5000 units intramuscularly, in divided doses, for the treatment of tetanus in children and adults, with part of the dose infiltrated around the wound. Doses of 250-500 units intramuscularly are given for postexposure prophylaxis. 

C. Human tetanus immune globulin. Supplied in single-dose vials containing 250 units. 

Amon, S. S. (1993) Clinical trial of human botulism immune globulin. In Botulinum and Tetanus Neurotoxins Neurotransmission and Biomedical Aspects (B. R. DasGupta, ed.), Plenum Press, New York. pp. 477-482. 

ACIP Advisory Committee on Immunization Practices CDC Centers for Disease Control and Prevention CMV-IVIG cytomegalovirus intravenous immunoglobulin DTaP diphtheria-tetanus-acellular pertussis vaccine HBIg hepatitis B immune globulin HDCV human diploid cell vaccine (rabies)... 

In addition to anthrax vaccine, the organization was a licensed producer of diphtheria and tetanus toxoids and pertusis vaccines, adsorbed immune serum globulin (human) pertusis vaccine adsorbed rabies vaccine adsorbed and tetanus toxoid, adsorbed. See Plotkin and Orenstein (1999), Appendix2, pp. 1190-1193. 

Injected forms of antibodies which have been generated in another body or animal can be isolated, purified, and administered as standard human immune serum globulin (ISG), and ISG plus preparation, or as an animal antiserum or antitoxin. Some serums which are available are those for rabies, snake and insect bites, botulism, and tetanus. Temporary immunity of up to six months to hepatitis can be imparted by one "gamma globulin" shot. More permanent active immunity is available to health care workers. 

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