Imaging time of flight secondary Ion mass spectrometry

Sjovall, P., Lausmaa, J., Nygren, H., Carlsson, L., and Malmberg, P. (2003). Imaging of membrane lipids in single cells by imprint-imaging time-of-flight secondary ion mass spectrometry. Anal. Chem. 75 3429-3434. 

Aubagnac, J.L., Enjalbal, C, Drouot, C, Combarieu R., Martinez, J. (1999) Imaging time-of-flight secondary ion mass spectrometry of sohd-phase peptide syntheses. /. Mass Spectrom., 34,749-754. 

A. Brunelle, D. Touboul and O. Laprevote, Biological tissue imaging with time of flight secondary ion mass spectrometry and cluster ion sources, Journal of Mass Spectrometry, 40,985 999 (2005). 

R. N. S. Sodhi, Time of flight secondary ion mass spectrometry (ToF SIMS) versatility in chemical and imaging surface analysis, Analyst, 129, 483 487 (2004). 

Seyer A, Riu A, Debrauwer L, Bourges-Abella N, Brunelle A, Laprevote O, Zalko D (2010) Time-of-flight secondary ion mass spectrometry imaging demonstrates the specific localization of deca-bromo-diphenyl-ether residues in the ovaries and adrenal glands of exposed rats. J Am Soc Mass Spectrom 21 1836-1845. doi 10.1016/j.jasms.2010.06.019... 

Luk SY, Patel N, Davies MC. Chemical imaging of pharmaceuticals by time-of-flight secondary ion mass spectrometry. Spectrosc Eur 2003 15(1) 14—18. 

Pacholski, M.L. et al., Static time-of-flight secondary ion mass spectrometry imaging of freeze-fractured, frozen-hydrated biological membranes, Rapid Commun. Mass Spectrom., 12, 1232, 1998. 

D. Touboul, F. Kollmer, et al. Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source, J. Am. Soc. Mass Spectrom. 16, 1608-1618 (2005). 

Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is a surface analysis technique used to analyze mass and image constituents that are present on the surface of materials. The equipment (Figure 12.47) uses a pulsed primary ion beam to desorb and ionize species from the sample surface. The resulting secondary ions are accelerated into a mass spectrometer and analyzed by measuring the ToF from the sample surface to the deteetor. The location and distribution of the species on the surface can be identified and an image shown at the detector. The composition is determined from the mass spectrum. Many different primary sources can be used for ionization ... 

Richter, K., Nygren, H., Maimberg, E, Hagenhoff, B. (2007) Localization of fatty acids with selective chain length by imaging the time-of-flight secondary ion mass spectrometry. Microsc. Res. Tech., 70, 640-647. 

Coullerez, G., Baborowski, J., Viornery, C., Chevolot, Y., Xanthopoulos, N., Ledermann, N., Muralt, R, Setter, N., Mathieu, H.J. (2003) Imaging by time-of-flight secondary ion mass spectrometry of plasma patterned metal and oxide thin films. Appl. Surf. ScL, 203,527-531. 

Roddy,T.P., Cannon, D.M. Jr., Meserole, C.A.,Winograd, N., Ewing, A.G. (2002) Imaging of freeze-fractured cells with in situ fluorescence and time-of-flight secondary ion mass spectrometry. Arud. Chem., 74,4011-4019. 

Touboul, D., Brunelle, A., Halgand, E, De La Forte, S., Laprevote, O. (2005) Lipid imaging by gold cluster time-of-flight secondary ion mass spectrometry application to Duchenne muscular dystrophy. J. Lipid Res., 46, 1388-1395. 

Impurity inclusions and surface defects are a cause of many difficulties to the polymer producer and user. Equipment used for studying these phenomena discussed in Chapter 4 include electron microprobe x-ray emission/spectroscopy, NMR micro-imaging, various forms of surface infrared spectroscopy, e.g., diffusion reflection FTIR, ATR, also photoacoustic spectroscopy and x-ray diffraction - infrared microscopy of individual polymer fibres. Newer techniques such as scanning electron microscopy (SECM), transmission electron microscopy, time of flight secondary ion mass spectrometry (TOFSIMS), laser induced photoelectron ionisation with laser desorption, atomic force microscopy and microthermal analysis are discussed. 

Mass spectrometry imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS) has revealed the spatial distribution of chemicals on a surface (1). When applied to biological samples, this method offers spatial information on biologically relevant small molecules (<1,000 Da). Indeed, ToF-SIMS imaging has been shown to be a powerful analytical tool for mapping the distribution of lipids on a cell membrane at the single-cell... 

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