Secondary-Ion Mass Spectrometry Imaging

Nevertheless, AP MALDI is generally less sensitive than vacuum MALDI due to the ion loss occurred during transferring from the ambient environment into the 

Even with those surface modifications and with the developments of cluster ion sources, the high-energy impaction process of SIMS often results in extensive 

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Lazof DB, Goldsmith JG, Rufty TW, Linton RW. The early entry of A1 into cells of intact soybean roots. A comparison of three developmental root regions using secondary ion mass spectrometry imaging. Plant Physiol 1996 112 1289-1300. 

Secondary Ion Mass Spectrometry Imaging Processing Methods... 

Seyer A, Riu A, Debrauwer L, Bourges-Abella N, Brunelle A, Laprevote O, Zalko D (2010) Time-of-flight secondary ion mass spectrometry imaging demonstrates the specific localization of deca-bromo-diphenyl-ether residues in the ovaries and adrenal glands of exposed rats. J Am Soc Mass Spectrom 21 1836-1845. doi 10.1016/j.jasms.2010.06.019... 

Pacholski, M.L. et al., Static time-of-flight secondary ion mass spectrometry imaging of freeze-fractured, frozen-hydrated biological membranes, Rapid Commun. Mass Spectrom., 12, 1232, 1998. 

M.G. Wolkenstein and M. Mutter, De-noising Secondary Ion Mass Spectrometry Image Sets Using A Three-Dimensional Wavelet Transformation, submitted to Analytical Chemistry (May 1998). 

L.A. Klerk, P.Y. Dankers, E.R. Pt ta, A.W. Bosman, M.E. Sanders, K.A. Reedquist, R.M. Heeren, TOF-secondary ion mass spectrometry imaging of polymer scaffolds with surrounding tissue after in vivo implantation. Anal. Chem. 82 (2010) 4337-4343. 

D. Touboul, F. Kollmer, et al. Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source, J. Am. Soc. Mass Spectrom. 16, 1608-1618 (2005). 

Robust Automated Three-Dimensional Segmentation of Secondary Ion Mass Spectrometry Image Sets. 

A. Brunelle, D. Touboul and O. Laprevote, Biological tissue imaging with time of flight secondary ion mass spectrometry and cluster ion sources, Journal of Mass Spectrometry, 40,985 999 (2005). 

K. Keune and J. J. Boon, Imaging secondary ion mass spectrometry of a paint cross section taken from an early Netherlandish painting by Rogier van der Weyden, Analytical Chemistry, 76, 1374 1385 (2004a). 

K. Keune, E. S. B. Ferreira and J. J. Boon, Characterization and localization of the oil binding medium in paint cross sections using imaging secondary ion mass spectrometry, Preprints of the 14th Triennial Meeting ofICOM CC Committee for Conservation, The Hague (Netherlands), 2, 796 802(2005). 

R. N. S. Sodhi, Time of flight secondary ion mass spectrometry (ToF SIMS) versatility in chemical and imaging surface analysis, Analyst, 129, 483 487 (2004). 

Secondary ion (mass spectrometry) SIMS Particle induced desorption/ ionization Nonvolatile molecular ions Semiconductors Surface analysis Imaging... 

Figure 38. Schematic and geometry of patterned thin-film LSM electrode on YSZ studied by Horita and coworkers. After establishing steady-state cathodic polarization, the atmosphere surrounding the electrode is rapidly switched from 02- to 02-rich for 10 min at fixed total Por The sample is then quenched to room temperature and postmortem analyzed using secondary-ion mass spectrometry (SIMS) imaging. (Reprinted with permission from ref 230. Copyright 2000 Elsevier.)...

Sjovall, P., Lausmaa, J., Nygren, H., Carlsson, L., and Malmberg, P. (2003). Imaging of membrane lipids in single cells by imprint-imaging time-of-flight secondary ion mass spectrometry. Anal. Chem. 75 3429-3434. 

Todd, P. J., Schaaff, T. G., Chaurand, P., and Caprioli, R. M. (2001). Organic ion imaging of biological tissue with secondary ion mass spectrometry and matrix-assisted laser desorption/ionization. J. Mass Spectrom. 36 355-369. 

It is a remarkable feature of secondary ion mass spectrometry (SIMS) that considerable chemical information is accessible through the procedurally simple physical technique of sputtering. SIMS--espec ia 11 y under low primary ion flux conditions ("static SIMS," a 1 s o known as "molecular SIMS" when applied to compounds)—provides information on molecular weight and molecular structure and allows isotopic analysis. The surface sensitivity of SIMS permits its use in imaging, in monitoring of surface... 

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