IgE-mediated allergy

Schad SG. Trcka J, Vieth S. Scheurer S. Conti A. Brbcker EB. Trautmann A Wine anaphylaxis in a German patient IgE-mediated allergy against a lipid transfer protein of grapes. Int Arch Allergy Immunol 2005 136 159-164. 

Positive basophil activation tests were reported in patients with immediate RCM hypersensitivity reactions, which may be regarded as another indirect indication for an IgE-mediated allergy [35]. 

Trcka J. Schmidt C, Seitz CS, et al Anaphylaxis to iodinated contrast material nonallergic hypersensitivity or IgE-mediated allergy AJR Am J Roentgenol 2008 190 666-670. 48... 

Garvey LH, Kroigaard M. Poulsen LK. Skov PS. Mosbech H, Venemalm L. Degerbeck F. Husum B IgE-mediated allergy to chlorhexidine. J Allergy Clin Immunol 2007 120 409. 

True IgE-mediated anaphylactic reactions to LAs are extremely rare [11-13]. Only single cases have been reported in the literature with positive prick tests [ 14,15]. A case of a positive open patch test in a patient suffering from contact urticaria after topical application of lidocaine, pilocaine mixture (Emla cream) might represent a true IgE-mediated allergy [16]. The maj ority of immediate-type reactions are non-immune in nature. 

A complement-independent mechanism of anaphylaxis would be classical allergy employing IgE antibodies. We found these antibodies to be elevated in only a few cases—possibly atopic individuals [142]. The serum of one of these children was used for passive sensitization of basophils of a healthy blood donor. The cells released histamine upon incubation of the cells with 1-ASP (Fig. 10). indicating that in some children IgE-mediated allergy may also play a role for clinical symptoms,... 

Atopic patients with single or multiple IgE-mediated allergy to foods... 

Crespo, J.F., Rodriguez, J., Vives, R. et al. 2001. Occupational IgE-mediated allergy after exposure to lupine seed flour. J Allergy Clin Immunol 108 295-297. 

Kraft D, Ferreira F, Vrtala S, Breiteneder H, Ebner C, Valenta R, Susani M, Breitenbach M, Scheiner O The importance of recombinant allergens for diagnosis and therapy of IgE-mediated allergies. Int Arch Allergy Immunol 1999 118 171-176. 

Metz, G., Bocher, D., Metz, J. (2001). IgE-mediated allergy to castor bean dust in a landscape gardener. Contact Dermatitis 44 367. 

The RAST Principle and the Use of Mixed-Allergen RAST as a Screening Test for IgE-Mediated Allergies... 

Dioun AF, Ewenstein BM, Geha RS, Schneider LC. IgE-mediated allergy and desensitization to factor IX in hemophilia B. J Allergy Clin Immunol 1998 102(1) 113-17. 

Among Austrian children living in a rural area, children living on a farm had less (hay fever) allergic rhinoconjunctivitis, asthma and other IgE-mediated allergies than those in a non-farming environment. Possible explanations include the development of immunotolerance or the stimulation of Thl cells and suppression of Th2 cells by increased exposure of farm children to microbial antigens in the stables or farmhouses [195(111)]. 

It also remains to be seen whether modification of aeroallergen exposure postnatally will have any impact on airway disease. One study combined dietary manipulation with HDM avoidance and showed a reduced prevalence of IgE-mediated allergy in the first 2 years of life but no effect on wheezing illnesses at 4 years of age [121]. Another study has shown that environmental manipulation to reduce pre- and postnatal exposure to HDM and animal allergens has reduced the frequency of respiratory symptoms in the first year of life in infants born to atopic families [122]. Longer-term follow-up and larger studies are required, and some are in progress. 

The production of antibodies known as IgE and a series of interactions between various cell types and chemical mediators are known to be involved in most confirmed cases of food allergy. This type of IgE-mediated allergy or type I hypersensitivity reaction produces immediate symptoms, the most severe form being anaphylaxis. Other immediate symptoms, such as rhinitis, urticaria, and other affections of the mouth, gut, skin, and respiratory tract, may precede anaphylaxis or occur alone as a less severe manifestation. These reactions would be considered as immediate hypersensitivities. Any food that contains protein has the potential to elicit such allergic sensitization. More than 170 different foods have been documented to be responsible for eliciting immediate hypersensitivities (Taylor, 2000). 

K Wrangsjo, JE Wahlberg, GK Axelsson. IgE-mediated allergy to natural rubber in 30 patients with contact urticaria. Contact Dermatitis 19 264-271, 1988. 

Any drug that can cause IgE-mediated allergy and anaphylactic reactions can also be responsible for bronchospasm (Charpin et al. 1972). However, this is seldom the only manifestation of allergy, unless the drug is delivered to the lungs by aerosol of by inhalation as a powder. Enzymes and macromolecular components such as pituitary snuff are well known to produce sensitization of that type. Sensitization to simple chemicals such as penicillin (Davies et al. 1974), spiramycin (Davies and Pepys 1975), or phenylmercuric propionate (Mathews and Pan 1968) can lead to asthmatic reactions through IgE-mediated mechanisms. The same has been described for the inhalation of other low-molecular-weight chemicals such as diisothiocyanate and platinum salts encountered in industrial applications (Pepys and Davies 1978). 

To establish IgE-mediated allergies to tetracyclines, Prausnitz-Kiistner tests were performed and positive results were obtained in some cases (Fellner and Baer 1966 Lochmannova et al. 1970). 

In a follow-up of 135 cases with reported and documented allergic reactions to local anesthetics there were two cases (1.5%) of true allergy and 7% had IgE-mediated allergy to other substances, such as chlor-hexidine or latex [2 ]. 

In contrast to the above results, the basophil activation test was positive to the implicated quinolone in all five subjects with immediate reactions to a quinolone who were tested [19 ]. However, this assay quantified CD203C, which may be a more sensitive marker than CD63 for detecting IgE-mediated allergy. 

Ben Said B, Berard F, Bienvenu J, Nicolas JF, Rozieres A. Usefulness of basophil activation tests for the diagnosis of IgE-mediated allergy to quinolones. Allergy 2010 65(4) 535-6. 

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