Hydrocortisone cream

Heat to 70°-75°C while stirring. Cool down the temperature to 65°C. 

Heat item 11 to 90°C in mixer. Dissolve items 9 and 10 to a clear solution by stirring. Cool down the temperature to 65°C. Maintain temperature at 65°-70°C. 

Transfer the oil phase to the aqueous phase in a mixer vessel through mesh by vacuum while stirring at manual mode, 10 rpm, temperature 60°C. 

Homogenize at high speed, temperature 60°C, vacuum 0.4 bar, 10 minutes. 

Cool down temperature to 45°C. Mix item 1 in 48.0 g of item 2 in a separate container at 45°C using homogenizer to make slurry. 

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This publication provides several examples of the use of solid-phase extractions for separating analytes from their matrices. Some of the examples included are caffeine from coffee, polyaromatic hydrocarbons from water, parabens from cosmetics, chlorinated pesticides from water, and steroids from hydrocortisone creams. Extracted analytes maybe determined quantitatively by gas (GC) or liquid chromatography (LG). 

A thin layer of hydrocortisone cream (0.25% to 1%) applied twice a day for no more than 2 weeks is an appropriate treatment regimen. The use of higher-potency steroids or use extending beyond 2 weeks should be at the discretion of a physician only. 

DEC2003 18DEC2003 Hydrocortisone Cream 102 06JAN2004 08JAN2004 Simethicone... 

NOV2003 10DEC2003 Rash 07DEC2003 18DEC2003 Hydrocortisone Cream... 

Assay of hydrocortisone cream with one-point calibration against an internal standard... 

Excellent separations of corticosteroids can be achieved on an ODS column with a suitable ratio of methanol/water as an eluent. In this assay hydrocortisone is quantified using betamethasone as an internal standard. The structure of betamethasone is close to that of hydrocortisone but since it is more lipophilic it elutes from the ODS column after hydrocortisone (Fig. 12.12). The assay is a modification of the BP assay for hydrocortisone cream. In the assay described here the internal standard is added at the first extraction step rather than after extraction has been carried out in order to ensure that any losses in the course of sample preparation are fully compensated for. Extraction is necessary in the case of a cream because the large amount of oily excipients in the basis of the cream would soon clog up the column if no attempt was made to remove them. The corticosteroids are sufficiently polar to remain in the methanol/water layer as they have a low solubility in hexane, while the oily excipients are removed by extraction into hexane. The sodium chloride (NaCl) is included in the sample extraction solution to prevent the formation of an emulsion when the extract is shaken with hexane. Solution 2, where the internal standard is omitted, is prepared in order to check that there are no excipients in the sample which would interfere with the peak due to the internal standard. 

Stated content of hydrocortisone cream = 1% w/w Weight of hydrocortisone cream used to prepare solution 3 = 1.173 g Area of hydrocortisone peak in Solution 1 = 103 026 Area of betamethasone peak in Solution 1 = 92 449 Area of hydrocortisone peak in Solution 3=113 628 Area of betamethasone peak in Solution 3 = 82 920 Concentration of hydrocortisone in the solution used in the preparation of Solution 1 = 0.1008% w/v... 

Cream 3% clioquinol and 0.5% hydrocortisone (Ala-Quin, Vioform-Hydrocortisone Mild Cream) 3% clioquinol and 1% hydrocortisone (Vioform-Hydrocortisone Cream, Dek-Quin). 

Cream (Rectal) 1% (Nupercainal Hydrocortisone Cream, Cortizone-10, Preparation H Hydrocortisone, Proctocort, Procto-Kit 1%), 2.5%(Anusol-HC, Hemorrhoidal HC, Procto-Kit 2.5%, Proctosol-HC, Proctozone-HC). 

A 22-year-old woman presents with a complaint of worsening psoriasis. She has a strong family history of the disease and has had lesions on her scalp and elbows for several years. She recently noted new lesions developing on her knees and the soles of her feet. She has been using topical over-the-counter hydrocortisone cream but admits that this treatment does not seem to help. What therapeutic options are available for the treatment of this chronic disease What risks are involved ... 

I headed to the shower to calm my nerves. Fat chance. The bathroom was like a House of Horrors. Can Soft Scrub residue get in your system via your feet What about the black mold dancing across our (plastic ) shower curtain And the roach bait behind the toilet The cat litter winked at me I recoiled. I brushed my teeth and almost cracked—was fluoride bad And what about my deodorant (aluminum), hydrocortisone cream (steroids), and just about every shampoo, lotion, and perfume on my shelf (all made with chemicals that have the potential to harm growing babies) Even my pedicure made me nervous, but I didn t dare risk acetone fumes to remove the poisonous polish. 

Frithz, A., Investigation of Cortesal , a hydrocortisone cream and its water-retaining cream base in the treatment of xerotic skin and dry eczemas, Curr. Ther. Res., 33, 930, 1983. 

The boy had recently been playing more outside in the yard, due to the hot weather, and his mother asked if the rash could have been caused by chiggers (larvae of mites that attached to the skin). With the patient s history of playing outdoors, and the characteristic linear vesicles, the doctor believed that the child had an allergic contact hypersensitivity reaction to poison ivy, and instructed the mother to apply cloths soaked in Burow s solution (aluminum acetate) until the vesicles crusted over. The mother was also told to thinly apply1% hydrocortisone cream (a low potency steroid) twice per day. 

Clioquinol Clioquinol cream Clioquinol ointment Clioquinol and Hydrocortisone cream Clioquinol and Hydrocortisone ointment Glass, 1.83 M x 2mm I.D. 3% G3/S1AB (80-100 mesh) Helium 165 FID Pyrene USP (24, pp. 435 and 436)... 

Heshmati S, Maibach HI. Active sensitization to sodium metabisulfite in hydrocortisone cream. Contact Dermatitis 1999 41(3) 166-7. 

Eubanks SW, Patterson JW. Dermatitis from sodium lauryl sulfate in hydrocortisone cream. Contact Dermatitis 1984 11(4) 250-251. 

Hydrocortisone preparations BP PC All subject to limit on particle size of Hydrocortisone or Hydrocortisone Acetate. See Hydrocortisone Acetate Ointment BP, Hydrocortisone Cream BPC, Hydrocortisone and Neomycin Cream BPC, Hydrocortisone and Neomycin Ear Drops and Eye Drops BPC, Hydrocortisone Eye Ointment BPC, Hydrocortisone Lotion BPC and Hydrocortisone Suppositories BPC... 

Medicines may also be exempted from POM classification if there are limitations on the use of the product. An example would be hydrocortisone cream 1% normally categorised as a POM but as a P medicine in packaging that limits the use of the cream to the treatment of allergic contact dermatitis, irritant dermatitis, insect bite reactions and mild to moderate eczema it should be applied sparingly once or twice a day for a maximum of one week. The P form or over-the-counter (OTC) form is only licensed for those indications and dosages listed above and further restriction to sales include unsuitability for OTC sale to treat ... 

A young girl, approximately 16 years old, wearing very fashionable clothes and lots of costume jewellery wants to buy some hydrocortisone cream she has seen recommended in her magazine. 

The rash is a typical sign of allergic contact dermatitis. Suggest that she stops wearing the watch and offer her some hydrocortisone cream 1%. Advise her to apply it thinly twice a day and use it for one week maximum. If after one week she sees no improvement, she should make an appointment to see her GP. 

Mild eczematous otitis externa affecting the pinna can be treated with hydrocortisone cream (see Chapter 27). 

Treatment consists in prescribing a cream containing steroid anti-inflammatories. The sooner treatment is started, the more effective it is with low-dose products. If treatment is delayed, higher doses of fluoro-corticosteroids have to be used, and the results are less satisfactory. A (2.5%) hydrocortisone cream or a topical clobetasone... 

Hydrocortisone Aqueous Gels (1 %) Hydrocortisone Cream (1%) Hydrocortisone Ethanolic Gel (0.5%)... 

Katsambas A, et al. A double-blind trial of treatment of seborrheic dermatitis with 2% ketoconazole cream compared with 1% hydrocortisone cream. Br J Dermatol 1989 353 121. 

In many cases of eczema, the use of emollients or astringents may not be sufficient to relieve the symptoms. Topical corticosteroids may then be required to reduce the inflammation. Corticosteroids come in different potencies and the potency of the preparation chosen should be appropriate to the severity of the condition. One percent hydrocortisone cream or ointment, which is available as a pharmacy medicine is usually effective. Long-term application of topical steroids can cause damage to the skin. The aim is to use the lowest effective concentration of corticosteroid for the shortest period. However, it is preferable to use a high potency steroid for a short period rather than a low potency steroid for a longer period. This minimizes the damage to the skin structure and reduces the possibility of systemic adverse effects. (See Chapter 7 page 119 and Table 7.1 for adverse effects of corticosteroids.)... 

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