Hydrocortisone 17-butyrate

PEROXIDES AND PEROXIDE COMPOUNDS - ORGANIC PEROXIDES] (Vol 18) llb,21-Dihydroxy-17-(l-oxobutoxy)-pregn-4-ene-3,20-dione. See Hydrocortisone butyrate. 

Hydrocortisone butyrate Locoid oint, soln 0.1% Intermediate... 

Examples of group I, i.e. weak or low efficacy topical steroids, are hydrocortisone acetate in various concentrations, methylprednisolone 1.0% and prednisolone 0.5%. Group II, the moderately potent steroids, includes alclometasone dipropionate 0.05%, hydrocortisone butyrate 0.1%, triamcinolone acetonide 0.025% and fluocinolone ace-tonide 0.01%. Group III, the potent steroids, contains among others betamethasone valerate 0.1%, betamethasone dipropionate 0.05%, budesonide 0.025%, desoximetasone 0.05%, fluticasone propionate 0.05%, amcinonide 0.1%, fluocinonide 0.05% and mometasone furoate 0.1%. Group IV comprises the very potent agents such as clobetasol propionate 0.05% and halobetasol propionate 0.05%. 

Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone valerate Mometasone furoate Prednicarbate Triamcinolone... 

A 58-year-old woman, who had been involved in the manufacturing of glucocorticoid creams and ointments for over 10 years, developed occupational contact sensitization to topical glucocorticoids (472). Patch tests were positive to hydrocortisone, hydrocortisone butyrate, and tixocortol pivalate. Intradermal tests were positive to hydrocortisone succinate, methylpredniso-lone, and prednisolone. An oral challenge with betamethasone 0.75 mg, 2.5 mg, and 8 mg on three consecutive days resulted in no adverse reactions. 

Equation (3.46a) indicates that the solubility of the solute in a mixed solvent system increases as the volume fraction of the cosolvent increases. Figure 3.6 shows the solubilization of hydrocortisone butyrate in a water/propylene glycol system. From the plot of Equation (3.46a), In x2m vs. solubilizing power, o, of the cosolvent for the solute. The solubilizing power is related to the partition coefficient of the solute in a water/octanol system, Kwo, as follows ... 

Figure 5.20 shows concentration-time profiles for the decomposition of hydrocortisone butyrate at 60°C in a buffered aqueous propylene glycol (50 w/w%, pH 7.6). Consecutive, irreversible, first-order kinetic models [i.e., Equation (5.119a), Equation (5.119b), and Equation (5.119c)] fit reasonably well with the experimental... 

Hydrocortisone Butyrate Buclizine 448.1 448.4 Benzethonium Chloride Pipamperone Hydrochloride 470.7 471.0 Enoxolone Alfentanil Hydrochloride... 

Fig. 6 Solubilization of different hydrocortisones in propylene glycol-water mixtures O, hydrocortisone acetate, hydrocortisone propionate, x, hydrocortisone butyrate, A. hydrocortisone pentanoate, g, hydrocortisone hexanoate, o, hydrocortisone heptanoate.

In most cases the DSC peak of the drug substance disappears and no new peak is observed. With hydrocortisone butyrate, " a new peak corresponding to the complex has been observed. For this drug, the... 

A woman had received intralesional paramethasone and other topical glucocorticoids several times for alopecia between the ages of 7 and 18 years (381). When she was 30 she was again treated with intralesional paramethasone for a relapse of alopecia. She developed pruritus after the first intralesional injection and erythema, edema, and vesicles 6-8 hours later. A biopsy showed spongiform lymphocytic folliculitis with spongiosis and exocytosis in the sweat gland ducts and in the pilosebaceous unit. She was treated with triamcinolone cream and her skin lesions resolved. Patch tests were positive for paramethasone, with cross-reactivity to tixocortol pivalate, hydrocortisone, and hydrocortisone butyrate. 

IK Chun, DS Yun. Inclusion complexation of hydrocortisone butyrate with cyclo-dextrins and dimethyl- 3-cyclodextrin in aqueous solution and in solid state. Int J Pharm 96 91-103, 1993. 

The cream, ointment, and topical solution contain the topical corticosteroid hydrocortisone butyrate, a nonflu-orinated hydrocortisone ester. It has the chemical name pregn-4-ene-3,20-dione, 11,21 -dihydroxy-17- [(1 -oxobu-tyl)oxy-,(ll(beta))- the molecular formula is C25H3606 and the molecular weight is 432.54. Each gram of cream contains 1 mg hydrocortisone butyrate in a hydrophilic... 

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