Hydrocortisone acetate suppositories

Hydrocortisone acetate is a corticosteroid designated chemically as pregn-4-ene-3,20-dione, 21-(acetyloxy)-ll,17-dihydroxy-(ll(beta)). Each rectal suppository contains hydrocortisone acetate USP 30 mg in a specially 

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What would be the displacement value of hydrocortisone acetate if it is known that ten suppositories containing 250 mg each of the drug weigh 20.83 g ... 

Hydrocortisone preparations BP PC All subject to limit on particle size of Hydrocortisone or Hydrocortisone Acetate. See Hydrocortisone Acetate Ointment BP, Hydrocortisone Cream BPC, Hydrocortisone and Neomycin Cream BPC, Hydrocortisone and Neomycin Ear Drops and Eye Drops BPC, Hydrocortisone Eye Ointment BPC, Hydrocortisone Lotion BPC and Hydrocortisone Suppositories BPC... 

Anti-hemorrhoid medication as hydrocortisone acetate, lidocaine and zinc sulphate in a fatty cream or ointment and zinc oxide in suppositories. 

Hydrocortisone (soluble in water 1 in 3,500) is better soluble than hydrocortisone acetate (practically insoluble in water). Therefore, in a suppository given for a systemic effect, hydrocortisone is used, but in a suppository given for local problems such as haemorrhoids, hydrocortisone acetate is preferred, in order to avoid unwanted systemic effects. 

Hydrocortisone sodium succinate is the available salt of hydrocortisone. It is not suitable for enemas because it is very unstable in aqueous solution. Alternatives are hydrocortisone or hydrocortisone acetate in a suspension enema or a suppository. For a systemic effect hydrocortisone is preferred because of its better solubility. Administration in a fatty suppository satisfies the requirements [51]. A suspension enema seems the better alternative, but literature does not provide a formula for a stable product. Therefore, in an enema the use of prednisolone or dexa-methasone sodium phosphate is preferred. Local effect may be achieved with hydrocortisone acetate, sometimes used in suppositories in the treatment of haemorrhoids. However, for this indication hydrocortisone acetate processed in a fatty cream is preferred. That dosage form minimises absorption as little cream will reach the rectum. 

Active substance should be rather troublesome to process but doesn t need to be practically relevant (for instance acetylsalicylic acid in suppositories hydrocortisone acetate to be dispersed in a cream base saHcyhc acid to be dispersed in white soft paraffin). 

System (6) was recommended for the analysis of hydrocortisone, cortisone, and their acetates in pharmaceutical preparations, as well as their separation from a number of impurities and decomposition products [154]. The sample (creams, ointments, lotions, or suppositories) was extracted with hot ethanol prior to introduction into the HPLC system. 

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