Human leukocyte antigen molecules

Structure of Class I Human Leukocyte Antigen Molecules... 

Albertini, M.R., Emler, C.A., Schell, K., Tans, K.J., King, D.M. and Sheehy, M.J. (1996) Dual expression of human leukocyte antigen molecules and the B7-1 co-stimulatory molecule (CD80) on human melanoma cells after particle-mediated gene transfer. Cancer Gene Ther., 3, 192-201. 

Family history of RA. Genetic studies demonstrate a strong correlation between RA and the presence of major histocompatibility complex class II human leukocyte antigens (HLA), specifically HLA-DR1 and HLA-DR4.4,5 HLA is a molecule associated with the presentation of antigens to T lymphocytes. 

First, we incubated immature dendritic cells (iDC) in the presence or absence of IRIV and could not observe upregulation of defined maturation markers. However, iDC incubation with supernatants harvested from IRIV stimulated PBMC cultures resulted in upregulation of CD86, human leukocyte antigen (HLA)-class I molecules, and, in most cases, also of CD83 (6). These results demonstrate that IRIV-induced cytokine secretion of PBMC indeed favors maturation of DC. 

Abs, Antibodies CD, celiac disease EM, endomysial antibodies GFD, gluten-free diet HLA-DQ2, human leukocyte antigen ICAM, intercellular adhesion molecule IFN, interferon IL, interleukin Lab laboratory tTG, tissue transglutaminase antibodies. 

As the human leukocyte antigen (HLA) class II molecules play a crucial... 

A key feature of l,25(OH)2D3 affected DCs is downmodulation of MHC class II molecules such as human leukocyte antigen (HLA-DR) which leads to reduced or... 

Fleckenstein B. Kalbacher H, Muller CP. Stoll D. Haider T. Jung G, Wiesmiiller K-H (1996) New ligands binding to the human leukocyte antigen class II molecule DRBI 0101 based on the activity pattern of an undecapeplide library, Eur J Biochem 240 71-77. 

Human leukocyte antigen (HLA). The major human histocompatibility complex situated on chromosome 6. Human HLA-A, -B, and -C (resembling mouse H2k, d, and 1) are MHC class I molecules, whereas HLA-DP, -DQ, and -DR (resembling mouse I-A and I-E) are MHC class II molecules. 

Human leukocyte antigens are polymorphic cell-surface molecules that are intimately involved in the regulation of the immune response. The antigens are encoded by a series of closely linked genes known as the major histocompatibility complex (MHC), which is located on the short arm of chromosome 6 (BIO). The complex extends over approximately 4000 kilobases or 4 x 10 nucleotides and contains three distinct subregions known as class I, class II, and class III (T19) (see Fig. 1). 

ACDy allergic contact dermatitis /CD, irritant contact dermatitis JL, interleukin HLA, human leukocyte antigen ICAMy intercellular adhesion molecule TNF, tumour-necrosis factor IFNy interferon GM-CSFy granulocyte-macrophage-colony-stimulating factor /P, IFN-induced protein M/P, macrophage inflammatory protein... 

Tissue type is determined hy molecules on the surface of every cell in the body. These molecules are called human leukocyte antigens (HLA) or the major histocompatibility complex (Petersdorfet et al. 1998 Villard 2006). Each person has unique HLAs. The HL As on the cells of the transplant signal to the body that this tissue is foreign, when a person receives a transplant, and stimulate an immune response. The recipient s blood usually is screened for antibodies against the tissues of the specific potential donor. If these antibodies are present severe rejection is expected, and transplantation will not be performed in these cases (Matas and Schnitzler 2004 Talbot and Manas 1997). 

Liu Z, Sun Y-K, Xi Y-P, Harris P, Suciu Foca N (1992) T cell recognition of self-human histocompatibility leukocyte antigen (HLA)-DR molecules. J Exp Med 175 1663-1668... 

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