T-cell recognition

Marincola, M. F. M., Jaffe, E. M., Hicklin, D. J., and Ferrone, S., 2000, Escape of human solid tumors from T-cell recognition Molecular mechanisms and functional significance, Adv. Immunol 74 181-273. 

Tellam J, Sherritt M, Thomson S, Tellam R, Moss DJ, Burrows SR, Wiertz E, and Khanna R (2001) Targeting of EBNAl for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+ T cell recognition. J. Biol. Chem. 276 33353-33360. 

The use of peptide libraries to study T cell specificity was first demonstrated by Gundlach et al.45 Since then studies have focused on T cell specificity with emphasis on the identification of immunodominant epitopes in infectious diseases and autoimmune disorders, and on the determination of tumor antigens. The PS-SCL approach, as described above, was successfully used to study T cell recognition and to identify and optimize peptides having a range of activities in stimulating proliferative responses, cytokine production, and/or lysis by CD4+ and CD8+ murine and human T cell clones and T cell lines of known and unknown specificity.46-53... 

D2. Davis, M. M., and Bjorkman, R J., T-cell antigen receptor genes and T-cell recognition. Nature... 

Graham CM, Barnett BC, Hartlmayr I et al (1989) The structural requirements for class II (I-Ad)-restricted T cell recognition of influenza hemagglutinin B cell epitopes define T cell epitopes. Eur J Immunol 19 523-528... 

Elsayed, S., Eriksen, J., Oysaed, L.K., Idsoe, R., and Hill, D.J. 2004. T cell recognition pattern of bovine milk alphaS 1-casein and its peptides. Mol Immunol 41(12) 1225-1234. 

De Libero, G.O., Moran, A.P, Gober, H.J., Rossy, E., Shamshiev, A., Chelnokova, O., Mazorra, Z., Vendetti, S., Sacchi, A., Prendergast, M.M., Sansano, S., Tonevitsky, A., Landmann, R., Mori, L. Bacterial infections promote T cell recognition of self-glycolipids. Immunity 22... 

Quarsten H, Molberg O, Fugger L, McAdam SN, Sollid LM. HLA binding and T cell recognition of a tissue transglutaminase-modified gliadin epitope. Eur J Immunol 1999 29 2506-2514. 

Stepniak D, Vader LW, Kooy Y, van Veelen PA, Moustakas A, Papandreou NA, et al. T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1. Immunogenetics 2005 57 8-15. 

M. Krummel, C. Wulfmg, C. Sumen, and M.M. Davis. 2000. Thirty-six views of T-cell recognition Pfe/ov. Trans. R. 

Major histocompatibility complex (MHC) proteins are essential components of the immune system (1). One speeific role is for them to bind and present cellularly derived peptides (-8-10 amino acids - MHC Class I peptides) at the cell surface. These peptides are subsequently challenged by cytolytic T-lymphocytes (CTL s) which are programmed to differentiate between self and exogenous peptides. T-cell recognition of these latter peptides initiates a response that ultimately results in cell lysis and death of the infected cell. Hence, structural characterization of such peptides could potentially result in the development of therapeutie treatments of a number of infectious disease states such as viral cancers, AIDS, and autoimmune disease. However, the task of sequencing such peptides is difficult since MHC class I proteins can bind and present 10,000-15,000 different cellularly derived peptides present at the sub-pieo-femtomole level (2,3). 

Identification of T-cell epitopes has revealed several alternative mechanisms by which MHC class I-restricted peptides are generated for T-cell recognition. The processing of these epitopes can be modulated at transcription/splicing, translation and protein degradation levels. 

Molecular components of T cell recognition. Annu. Rev. Immunol. 10, 835-873. 

Padovan E, Mauri-Hellweg D, Pichler WJ, et al. T cell recognition of penicillin G Structural features determining antigenic specificity. Eur / Immunol. 1996 26 42-48. 

Shimizu, Y., van Seventer, G., Morgan, K. J., and Shaw, S., Role of adhesion molecules in T-cell recognition. Fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-6) in expression, binding and costimulation, Immunol. Rev., 114, 109, 1992. 

All SAgs bind to MHC class II as a prerequisite for T cell recognition. The molecular mechanism of this interaction is not only different from the binding... 

Chen W. McCluskey J. Rodda S, Carbone FR (1993) Changes at peptide residues buried in the major histocompatibility complex (MHC) influence T cell recognition a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition, J Exp Med 177 869-873. 

MARTIN, S. WELTZIEN, H.U. (1994) T cell recognition of haptens a molecular view. 

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