Dengue—2 virus

Melino S, Paci M (2007) Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach. FEES J 274 2986-3002 Murphy RL, Brun S, Hicks C, Eron JJ, GuUck R, King M, White AC Jr, Benson C, Thompson M, Kessler HA, Hammer S, Bertz R, Hsu A, Japour A, Sun E (2001) ABT-378/ritonavir plus stavudine and lamivudine for the treatment of antiretroviral-naive adults with HIV-1 infection 48-week results. AIDS 15 E1-E9... 

Kumarasamy, V. Wahab, A. H. A. Chua, S. K. Hassan, Z. Chem, Y. K Mohamad, M. Chua, K. B., Evaluation of a commercial dengue NS1 antigen capture ELISA for laboratory diagnosis of acute dengue virus infection, J. Virolog. Methods 2007, 140, 75 79... 

Diamond MS, Zachariah M, Harris E. (2002) Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA. Virology 304 211-221. 

Takhampunya R, Ubol S, Houng HS, Cameron CE, Padmanabhan R. (2006) Inhibition of dengue virus replication by mycophenolic acid and ribavirin./Gen Virol S7 1947-1952. 

Whitby K, Pierson TC, Geiss B, Lane K, Engle M, Zhou Y, Dorns RW, Diamond MS. (2005) Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol 79 8698-8706. 

Krishna Murthy, H. M., et al. (1999). Crystallization, characterization and measurement of MAD data on crystals of dengue virus NS3 serine protease complexed with mung-bean Bowman-Birk inhibitor. Acta Crystallogr D 55,1370-1372. 

Murthy, H. M., et al. (2000). Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor implications for flaviviral polyprotein processing and drug design. /. Mol. Biol. 301, 759-767. 

Murthy, H. M., Qum, S. and Padmanabhan, R. (1999). Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects. J. Biol. Chem. 274, 5573-5580. 

Anthelmintic, antiprotozoal, anti-neoplastic, and antiviral agent Binds many proteins, i.e., cytokines. epidermal growth factor, and members of the FGF family inhibits dengue virus infec-tivity of host cells very long in vivo half-life, exhibits a wide range of toxic side effects 40-47... 

Y Chen, T Maguire, RE Hileman, JR Fromm, JD Esko, RJ Linhardt, RM Marks. Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate. Nature Med 3 866-871, 1997. 

S1L Hung, PL Lee, HW Chen, LK Chen, CL Kao, CC King. Analysis of the steps involved in dengue virus entry into host cells. Virology 257 156—167, 1999. 

RM Marks, H Lu, R Sundaresan, T Toida, A Suzuki, T Imanari, MJ Hernaiz, RJ Linhardt. Probing the interaction of dengue virus envelope protein with heparin assessment of glycosaminoglycan-derived inhibitors. J Med Chem 44 2178-2187, 2001. 

Abstract The inhibitory action of polyanionic substances on virus replication was reported more than 50 years ago. Seaweeds, marine invertebrates, and higher plants represent abundant sources of novel compounds of proved antiviral activity. Natural sulfated polysaccharides (SPs) are potent in vitro inhibitors of a wide variety of enveloped viruses, such as herpes simplex virus (HSV) types 1 and 2, human immunodeficiency virus (HIV), human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and influenza A virus. Several polysulfate compounds have the potential to inhibit virus replication by blocking the virion binding to the host cell. In contrast, their in vivo efficacy in animal and human systemic infections has undesirable draw-... 

Pujol et al. in chapter eight, reviews the chemistry, origin and antiviral activities of naturally occurring sulfated polysaccharides for the prevention and control of viral infections such as HIV-1 and -2, human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and influenza A virus. 

P. C.de S. F. Tischer, L. B. Talarico, M. D. Noseda, S. M. P. B. Guimaraes, E. B. Damonte, and M. E. R. Duarte, Chemical structure and antiviral activity of carrageenans from Meristiella gelidium against herpes simplex and dengue virus, Carbohydr. Polym., 63 (2006) 459 165. 

Although there are mechanistic differences between retroviruses, paramyxoviruses, and the orthomyxovirus influenza, the viruses discussed to this point have definite structural and functional similarities including spikelike, trimeric native structures and the presence of coiled coils in their fusion-active subunits. The flaviviruses and alphaviruses, however, appear to be another class of enveloped viruses entirely. Flaviviruses include yellow fever. West Nile virus. Dengue virus, and tick-borne encephalitis virus (TBEV). Alphaviruses, of the togavirus family, include... 

Markoff, L., Falgout, B., and Chang, A. (1997). A conserved internal hydrophobic domain mediates the stable membrane integration of the dengue virus capsid... 

Fig. 22.20 Possible phylogenetic scheme of the HCV (Hepaciviri-dae) and GB viruses (especially GBV C/HGV) as well as other members of the Flaviviridae (I) DV = Dengue virus, WNV = West Nile virus, JEV = Japanese encephalitis virus, YFV = yellow...

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