Virus inhibition

Hagiwara T, Kijima-Suda I, Ido T, Ohrui H, Tomita K (1994) Inhibition of bacterial and viral sialidases by 3-fluoro-V-acetyIneuraminic acid, Carbohydr Res 263 167-172 Haskell TH, Peterson FE, Watson D, Plessas NR, Culbertson T (1970) Neuraminidase inhibition and viral chemotherapy, J Med Chem 13 697-704 Hatakeyama S, Sugaya N, Ito M, Yamazaki M, Ichikawa M, Kimura K, Kiso M, Shimizu H, Kawakami C, Koike K, Mitamura K, Kawaoka Y (2007) Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors, JAMA 297 1435-1442 Hay AJ (1992) The action of adamantanamines against influenza A viruses inhibition of the M2 ion channel protein, Semin Virol 3 21-30... 

HIV-1, RNase H enzyme, 46 307 HIV virus, inhibition by bis(cyclam) derivatives, 45 76... 

By carefully adjusting the distances between two sialoside residues in a number of divalent clusters. Click and Knowles [105] have obtained dimer 104 having the two sialic acid 5.7 nm apart. Compound 104 was 100-fold more potent than methyl a-sialoside (Neu5Aca2Me) in influenza virus inhibitions and 500-fold more potent in the case of polyomia virus. Alternatively, sialyl-a-(2,6)-/3-LacNAc dimers (105) branched at different positions of synthetic peptides, including compact glycine-rich and helical proline-rich peptides, afforded clusters which were only 8- and 4-fold more potent, respectively, than the corresponding monovalent trisaccharide [106]. 

A. J. Hay, The action of adamantanamines against influenza A viruses Inhibition of the M2 ion channel protein, Semin. Virol., 3 (1992) 21-30. 

Wacker, A. and Hilbig, W. 1978. Virus-inhibition by Echinacea purpurea (Author s Transl). Planta... 

Inhibition of herpes simplex virus Inhibition of herpes simplex virus Inhibition of herpes simplex virus Inhibition of herpes simplex virus... 

Antiviral activities Inhibition of herpes simplex virus Inhibition of Rauscher virus NIH/3T3 cells Inhibition of herpes simplex virus Inhibition of herpes simplex virus Inhibition of herpes simplex virus Inhibition to Rauscher virus NIH/3T3 cells Inhibition of herpes simplex virus Inhibition to Rauscher virus NIH/3T3 cells Inhibition to Rauscher virus NIH/3T3 cells Inhibition of herpes simplex virus Inhibition of murine sarcoma virus Inhibition to Rauscher virus NIH/3T3 cells Inhibition of herpes simplex virus Inhibition to Rauscher virus NIH/3T3 cells Inhibition to Rauscher virus NIH/3T3 cells Inhibition of herpes simplex virus Inhibition to Rauscher virus NIH/3T3 cells Inhibition of herpes simplex virus Inhibition of potato x virus... 

Fig. 10 shows the viral yields obtained on days 2, 3,4 and 5 after the infection, in control cultures and in cultures treated with distamycin-5. The inhibition of virus production was almost constant on any day tested, suggesting that an early step in virus multiplication is blocked. Similar results were obtained with distamycin-4, but virus inhibition was less than with distamycin-5. 

Song W, Liu G, Bosworth CA et al (2009) Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase. J Biol Chem 284(11) 7294-7306... 

Distamycin A (309) is an oligopeptide, isolated from Streptomyces distallicus that inhibits transcription and replication of DNA viruses along with its other related semisynthetic analogs [18]. Example of DNA viruses inhibited by this group are vaccinia virus and HSV-1. Distamycin A also shows inhibitory activity for RT of retroviruses [18]. 

The synthetic tridecamer, which is complementary to 13 bases of the 3 - and 5 -reiterated terminal sequences of Rous sarcoma virus 35S RNA," was added to chick embryo fibroblast tissue cultures infected with Rous sarcoma virus. Inhibition of virus production resulted. This is because the synthetic oligomer hybridizes with the terminal reiterated sequences at the 3 -and 3 -ends of the 35S RNA and interferes with one or more steps involved in viral production and cell transformation. 

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