Hormones specificity

Hormone-specific antibodies are the key to the radioimmunoassay. Purified hormone, injected into rabbits, elicits antibodies that bind to that hormone with very high affinity and specificity. When a constant amount of isolated antibody is incubated with a fixed... 

Production of a number of different hormones from the same precursor allows coordinate production of several hormones. Specific cleavage by the cell allows control of which peptides are produced (e.g., cleavage of prepro-opiocortin to corticotropin, /3-lipotropin, y-lipotropin, a-MSH, /3-MSH, y-MSH, endorphin, and enkephalin). 

Verrijdt G, Haelens A, Claessens F. Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. Mol GenetMetab. 2003 78 175-185. 

Illustration of Some Alternative Approaches by Reagents Directed Towards Steroid— Hormone-Specific Targets... 

The study of potential paracrine modulators (estrogens, androgens and growth factors) that could enhance FSH action led to the development of an in vitro granulosa cell aromatase bioassay (GAB). The combined action of enhancing hormones and factors resulted in an assay highly sensitive to the aromatase-inducing function of FSH [69], This assay is hormone-specific and sensitive, and has been applied to the measurement of FSH bioactivity in serum [70] and urine samples [71] from humans and diverse animal species. 

Mauer RA (1982a) Thyroid hormone specifically inhibits prolactin synthesis and decreases prolactin messenger ribonucleic acid levels in cultured pituitary cells. Endocrinology 770 1507-1514. 

Interaction of the receptor with the ligand is hormone-specific.22... 

Hormone Specific activity of labeled hormone itiCi/iig) Material assayed Sensitivity Reference... 

A number of drugs have an inhibitory effect on one or more steroidogenic/steroid modifying enzymes, and some of these are used clinically to inhibit the production of certain steroid hormones. Some of the important drugs used for this purpose are broad spectrum while others are hormone-specific a few are listed below along with their principle therapeutic use ... 

The a subunits of all pituitary glycoprotein hormones are identical but show minor differences from the a subunit of hCG. The subunits differ in all and confer hormonal specificity. The association of a and subunits is required for activity, but the subunits need not be homologous. Dissociation of the subunits of one hormone, followed by recombination with subunits of another hormone, results in hybrids that are biologically active and exhibit the biological activity characteristic of the y3 subunit. For example, the hybrids LH-a/FSH-j8 have FSH activity, while TSH-a/LH-/3 have LH activity. 

This compound is a naturally occurring metabolite of the amino acid GABA. Before it was removed from the over-the-counter market, supplement distributors purported GHB ability to increase natural growth hormone secretion. These claims were based on a 1977 study by the Third Department of Internal Medicine, Okayama University School of Medicine, Okayama Japan. In this study, it was discovered that GHB has a significant effect on pituitary hormones, specifically growth hormone... 

Hormones Specific proteins Trace elements Vitamins Dnigs... 

Because insulin promotes biosynthesis, insulin can be considered a growth hormone. Specific effects of insulin include the following ... 

The proteins and cells in the blood form their own tissue system (see Chapter 44). All blood cells are derived from a common precursor, the stem cell, in the bone marrow. Different cytokine signals trigger differentiation of a particular blood cell lineage. For example, when there is a decreased supply of oxygen to the tissues, the kidney responds by releasing erythropoietin. This hormone specifically stimulates the production of red blood cells. 

Both LH and FSH are referred to as gonadotropins, beoause they aot on the male and female gonads, which results in the production of the sex steroids testosterone and estradiol, respectively. In the female, FSH and LH act in concert in regulating ovarian function egg maturation, ovulation, and transformation of the ruptured follicle into the corpus luteum. In males, spermatogenesis is dependent on these two hormones. Specifically, FSH in females facilitates the maturation of ovarian folliole oells and their secretion of estradiol, whereas in males, it stimulates the maturation of sperm in the testes. In females, LH promotes ovulation, formation of the oorpus luteum, and progesterone secretion in males, it enables the secretion of testosterone from the testes. 

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