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Pituitary hormones glycoprotein

Chorionic gonadotropin (CG) is produced in the placenta. Together- with the pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), it constitutes the glycoprotein family of gonadotropins. The actions of CG are mediated by the LH receptor, both belonging to the superfamily of G-protein Coupled Receptors. [Pg.361]

Another example of processing of glycoproteins is found in the synthesis of pituitary hormones. ACTH, /3LPH, a-MSH, and /3-endorphin are synthesized from a common precursor in the neurointermediate lobe. Controlled, proteolytic cleavage liberates the final products, which are then secreted. Numerous other examples could be mentioned.3SS 393... [Pg.357]

Pituitary hormones, Tamm-Horsfall glycoprotein, urokinase... [Pg.1739]

Anterior pituitary hormones are classihed into three families the somatomammotropin family (GH and PRL), the glycoprotein hormones (LH, FSH, and TSH), and the opiomelanocortin family (ACTH, /i-endorphin, and related peptides). These three families appear to have evolved from three separate ancestral polypeptides homologous members of each family occur in other parts of the body. For example, human placental lactogen (hPL) is somatomammotropic, human chorionic gonadotrophin (hCG) is a glycoprotein hormone, and the brain and gut produce substances related to endorphins (enkephalins and dynorphin). [Pg.737]

Anterior pituitary Thyrotropin (TSH) Luteinizing hormone Glycoproteins... [Pg.42]

Fig. 2. Generalized structure of N-linked oligosaccharide of the pituitary glycoprotein hormones. SO = sulfate, GIcNAc = N — acetylglucosamine, GalNAc = N — acetylgalactosamine, Man = mannose, Fuc = fucose, SA = sialic (neuraminic) acid. Fig. 2. Generalized structure of N-linked oligosaccharide of the pituitary glycoprotein hormones. SO = sulfate, GIcNAc = N — acetylglucosamine, GalNAc = N — acetylgalactosamine, Man = mannose, Fuc = fucose, SA = sialic (neuraminic) acid.
Inhibin and Activin. Inhibin, a water-soluble, gonadal factor known for over 50 years to inhibit pituitary function, has been isolated and identified (127—130). Inhibin is a glycoprotein hormone that preferentially inhibits the secretion of FSH. It consists of an a-chain subunit, mol wt 14,000, linked by disulfide bonds to a P-chain subunit, mol wt 18,000. There exist two forms of the P-chain subunit, P-A and P-B. The smaller subunit combines with either the P-A or P-B subunit to form inhibin-A or inhibin-B, respectively. [Pg.123]

The gonadotropins are produced by the anterior pituitary (adenohypophysis) and the placenta. This group of glycoproteins (carbohydrate-containing proteins) includes the following hormones ... [Pg.346]

The testes and ovaries synthesize hormones necessary for physical development and reproduction. A single hypothalamic-releasing factor, gonadotropin-releasing hormone, stimulates the anterior pituitary to release the glycoproteins, luteinizing hormone (LH) and... [Pg.237]

Luteinizing Hormone (LH) (Luteotropin. 1SCH) Structure Globular glycoprotein with S—S bridges. Molecular Weight 26.000 Production Site Anterior pituitary. ... [Pg.787]

Siddle, K., and Soons, M., Monoclonal antibodies for human pituitary glycoprotein hormones and rabbit immunoglobulin. In "Monoclonal Antibodies and Developments in Immunoassay" (A. Albertini and R. Ekins, eds.), pp. 53-66. Elsevier, Amsterdam, 1981. [Pg.108]

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See also in sourсe #XX -- [ Pg.1745 ]



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