Hormones, specific agents

The presence of antibodies to a specific agent is evidence of exposure to that antigen. Blood tests can then be devised to test for those antibodies leading to the detection of disease states as well as quantiation of hormonal levels and drug exposures. 

Regardless of the specific agent or regimen, menopansal hormone therapy with estrogens shonld nse the lowest dose and shortest duration necessary to achieve an appropriate therapeutic goal. 

A somewhat related sequence leads to trilostane (111), a compound that inhibits the adrenal gland more specifically the agent blocks some of the metabolic responses elicited by the adrenal hormone ACTH in experimental animals. Reaction of the hydroxy-methylene derivative 108, obtained from testosterone, with hydroxylamine gives the corresponding isoxazole (109). Oxidation of the C-4,5 double bond by means... 

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