Natural hormones

It was known as early as 1927 that the adrenal glands of mammalian species secrete a series of substances essential to the survival of the individual. The hormonal nature of these secretions was suggested by the observation that extracts of the adrenal gland and more specifically of the outer portion of that organ (cortex) would ensure survival of animals whose adrenals had been excised. By 1943 no fewer than 28 steroids had been isolated from adrenal cortical extracts. These compounds were found to be involved in the regulation of such diverse and basic processes as electrolyte balance, carbohydrate metabolism, and resistance to trauma, to name only a few. 

Horizontale,/. horizontal (line). Horizontierung, /. leveling. Hormonabsonderung, /. hormone secretion, hormonartig, a. of hormone nature, hormonal, hormone-like. 

Goeddel D.V., Heyneker H.L., Hoxumi T., Arentzen R, Itakura K., Yansura D.G, Ross M.J., Miozzari G, Crea R Seeburg P.H. (1979) Expression in Escherichia coli of a DNA sequence coding from human growth hormone. Nature, 281, 544-548. 

Burton, J.L., Shuster, S., Cartlidge, M., Libman, L.J., and Martell, U. (1973). Lactation, sebum excretion and melanocyte-stimulating hormone. Nature 243, 349-350. 

Grepafloxacin Growth Hormone (natural) Raxar Crescormon Quinolone antibiotic Hormone... 

R Schwyzer, P Sieber. The total synthesis of adrenocorticotrophic hormone. Nature 199, 172, 1963. 

Triacana is a trade or brand name for the thyroid drug Tiratricol. The body naturally (endogenously) produces T-4/L-thyroxine, T-3/L-triiodothyronine, and T-2 /L-diiodothyronine. Triacana is simply a synthetic form of these three thyroid hormones natural metabolite product, Triiodothyroacetic acid, or tiratricol for short. This means the body naturally produces Triacana as a metabolic by-product of other thyroid hormones. 

Major developments in the metabolic study came after selective JH and I7 C labeled vitamin Do with high specific activities were synthesized in the mid-1960 s. Since then, massive efforts by a number of investigators have led to the discovery of a large number of metabolities, the hormonal nature of the primary metabolities in the maintenance of... 

Bimbaumer M, Seibold A, Gilbert S, Ishido M, Barberis C, Antaramian A, Brabet P, Rosenthal W. Molecular cloning of the receptor for human antidiuretic hormone. Nature 1992 357(6376) 333—335. 

It is now well established that l,25-(OH)2D3 is the active hormonal form of vitamin D3 [32], The production of l,25-(OH)2D3 in the kidney is regulated by dietary calcium and phosphate and also by changes in serum calcium and parathyroid hormone, which clearly highlight the hormonal nature of this compound. Functionally, the three classical actions of l,25-(OH)2D3 are to stimulate intestinal calcium and independently phosphate absorption, the mobilization of calcium from bone, and increase renal reabsorption of calcium. The focus of this review will be to explore the most recent concepts of vitamin D in regard to its metabolism and physiology, and with respect to the medicinal applications of vitamin D3 metabolites and analogues. 

Schwyzer R, Sieber P. Total synthesis of adrenocorticotropic 119. hormone. Nature 1963 199 172-174. 

G8. Gray, C. J., Molecular weight of human follicle stimulating hormone. Nature (London) 216, 1112-1113 (1967). 

L2. Li, C. H., and Starman, B., Molecular weight of sheep pituitary interstitial cell-stimulating hormone. Nature (Ijmdon) 202, 291-292 (1964). 

B. Cardenolides They have C 17 position unsaturated lactone. They are cyclo-pentanophenantheme derivatives and have hormonal nature. They act on kidney and heart. Digitalis glycosides belong to this group. 

M23. Moses, A. C., Nissley, S. P., Cohen, K. L., and Rediler, M. M., Specific binding of somatomedin-like polypeptide in rat serum depends on growth hormone. Nature (London) 263, 137-140 (1976). 

Biochemical pesticides include, but are not limited to, products such as semiochemicals (e.g., insect pheromones), hormones (e.g., insect juvenile growth hormones), natural plant and insect regulators, and enzymes. When necessary the Agency will evaluate products on an individual basis to determine whether they are biochemical or conventional chemical pesticide. ... 

The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature, 324, 635-640. 

Bacskai BJ, Friedman PA. Activation of latent Ca2+-channels in renal epithelial cells by parathyroid hormone. Nature 1990 347 388-391. 

Most approaches are based on combinations of the drug with a polymer. The latter serves as a carrier system wherein the drug is dispersed or dissolved, or to which it is covalently linked. Cells, microspheres, nanospheres, liposomes, proteins, antibodies, hormones, natural and synthetic... 

McGiff, J.C., Crowshaw, K., Terragno, N.A. and Lonigro, A.]. (1970). Renal prostaglandins possible regulators of the renal actions of pressor hormones. Nature (London), 227, 1255-1257... 

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