Digitalis glycosides ,

Lldoc ine. Lidocaine hydrochloride, an anilide, was originally introduced as a local anesthetic in 1943 and found to be a potent antiarrhythmic in 1960. The compound is a reverse amide of procainamide. Lidocaine is generally considered to be the dmg of choice in the treatment of ventricular arrhythmias and those originating from digitalis glycoside toxicity (1,2,15—17). 

Glandular products, drugs of vegetable origin, such as quinine, strychnine and brucine, emetine, and digitalis glycosides ... 

Digitalis glycosides Apply the sample solution as a band, then cover the layer, apart from the application zone, with a glass plate and place it in an ammonia chamber for 24 to 48 h, remove excess ammoma and chromatograph Acetyl groups are split off [37]... 

Digitalis glycosides Apply sample solution as band and then luizyme solution over it if necessary, moisten the application zone with water. Cover the layer, except for the application zone, with a glass plate and incubate at 39 °C for 2 to 5 h. [37]... 

Liquid paraffin digitalis glycosides stabilization and enhancement 30% in chloroform [242]... 

Fig. 1 Fluorescence scan of a mixture of digitalis glycosides. Digoxin (DG3), digoxigenin bis-digitoxoside (DGj), digoxigenin mono-digitoxoside (DGi), digoxigenin (DG).

The digitalis glycosides yielded blue fluorescent zones in long- wavelength UV light (A = 365 nm) (Fig. 1). 

Fhtients taking a diuretic and a digitalis glycoside must be monitored closely. Thiazide and loop diuretics (see Chap. 46) may increase the risk and effects of toxicity. 

The most common imbalances are a loss of potassium and water. Other electrolytes, namely magnesium, sodium, and chlorides, are also lost. When too much potassium is lost, hypokalemia (low blood potassium) occurs (see Home Care Checklist Preventing Potassium Imbalances). In certain patients, such as those also receiving a digitalis glycoside or those who currently have a cardiac arrhythmia, hypokalemia has the potential to create a mo re serious arrhythmia Hypokalemia is... 

CARD IAC ARRHYTH MI AS AN D DIZZIN ESS. Patients receiving a diuretic (particularly a loop or thiazide diuretic) and a digitalis glycoside concurrently require frequent monitoring of the pulse rate and rhythm because of the possibility of cardiac arrhythmias. Any significant changes in the pulse rate and rhythm are immediately reported to the primary health care provider. 

Digitalis glycosides that react well with various chloramine T - trichloroacetic acid or mineral acid reagents are not excited to fluorescence after treatment with chloramine T — sodium hydroxide. 

Digitalis glycosides yield yellow or blue fluorescent chromatogram zones on a dark background when examined under long-wavelength UV light (X = 365 nm) [1, 4, 5-7]. 

The detection limits for digitalis glycosides are 12-50 ng substance per chromatogram zone [2, 8]. 

For instance, trenbolone fluoresces yellow [12] and the qinoxalone derivative of pyruvic acid yellow-green [18]. In the case of steroids and Digitalis glycosides it is possible to differentiate on the basis of various fluorescence colors [8, 9, 15]. 

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