Triiodothyroacetic acid

Chemical Name [4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl] acetic acid Common Name Triiodothyroacetic acid Structural Formula ... 

Tiratricol All products containing tiratricol 11/22/2000 Tiratricol also known as triiodothyroacetic acid or TRIAC, is a potent thyroid hormone that may result in serious health consequences... 

Trace levels of T-2 (L-diiodothyronine) and Triacana (Triiodothyroacetic Acid)... 

Triacana is a trade or brand name for the thyroid drug Tiratricol. The body naturally (endogenously) produces T-4/L-thyroxine, T-3/L-triiodothyronine, and T-2 /L-diiodothyronine. Triacana is simply a synthetic form of these three thyroid hormones natural metabolite product, Triiodothyroacetic acid, or tiratricol for short. This means the body naturally produces Triacana as a metabolic by-product of other thyroid hormones. 

Abbreviations 3,5,3, 5 -tetraiodothyronine or thyroxine, T4 3,5,3-triiodothyronine, T, 3,3, 5 -triio-dothyronine, reverse T, or r-T3 3,5,3, 5 -tetraiodothyroacetic acid, TETRAC 3,5,3 -triiodothyroacetic acid, TRIAC 3,5-diiodotyrosine, DIT 3-monoiodotyrosine, MIT thyrotropic hormone, TSH thyreo-liberin, TRH growth hormone, GH microtubule associated proteins, MAPs TAU protein, one of the brain MAPs. 

TNS 227), and triiodothyroacetic acid (229) bind competitively to ANS. Triiodothyronine (230,231) and thyroxine (59,230) have also been shown to bind to LADH and to interfere with coenzyme binding. There is, however, conflicting evidence regarding the detailed mode of inhibitory action. 

T. Takeda, S. Suzuki, R.T. Liu, L.J. DeGroot, Triiodothyroacetic acid has unique potential for therapy of resistance to thyroid hormone, J. 

ABBREVIATIONS DIT, diiodotyrosine MIT, monoiodotyrosine T S, T sulfate T G, T glucuronide T3S, T3 sulfate T3G, T3 glucuronide T, K, T, pyruvic acid T3K, T3 pyruvic acid Tetrac, tetraiodothyroacetic acid Triac, triiodothyroacetic acid. 

There has been much speculation that some compound formed in the peripheral tissues might be the active hormone. This speculation has been prompted by the fact that there is usually a latent period of hours or even days before the occurrence of a detectable response to an injection of L-thyroxine. 3,5,3 -L-Triiodothyronine has a considerably shorter latent period than L-thyroxine in man it has therefore been su ested that partial deiodination might produce the peripherally active compound. However, the rate at which, and extent to which, L-thyroxine is converted by the peripheral tissues to L-triiodothyronine is not of sufficient magnitude to lend support to this suggestion (cf. Pitt-Rivers and Tata, 1959). The report by Thibault and Pitt-Rivers (1955) that tetraiodothyroacetic acid and triiodothyroacetic acid have an immediate action on oxidative processes... 

Tyrosine, 3-monoiodotyrosine, 3,5-diiodotyrosine, 3,5,3 -triiodothyronine (T3), and 3,5, 3 -triidothyronine (reverse T3) were baseline resolved on a C,g column (A = 254 nm) with a 50/49/1 acetonitrile/water/acetic acid mobile phase [1249]. Linear concentration curves fiom 40 to 800 ng injected were generated. In the same study, a set of 14 thyroacetic acids and iodoamino acids were baseline resolved and eluted in 25 min. Here a Cig column and a 60-min 10/90 ->75/25 acetonitrile/ water (0.1% H3PO4) gradient were used. Some of the additional analytes included 3,5-diiodothyroacetic acid, 3,3, 5-triiodothyroacetic acid, and 3, 5 -diiodotfiyronine. 

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