Hemolytic syndrome

Alcohol indirectly affects hematopoiesis through metabolic and nutritional effects and may also directly inhibit the proliferation of all cellular elements in bone marrow. The most common hematologic disorder seen in chronic drinkers is mild anemia resulting from alcohol-related folic acid deficiency. Iron deficiency anemia may result from gastrointestinal bleeding. Alcohol has also been implicated as a cause of several hemolytic syndromes, some of which are associated with hyperlipidemia and severe liver disease. 

All the new synthetic antimalarials may apparently be administered safely to the pregnant woman, but it is a firmly entrenched clinical impression that quinine in full dosage is contraindicated in the mother and may cause serious visual and oral disturbances in the infant. Black-water fever, a little-understood hemolytic syndrome sometimes complicating P. falciparum cases, has been associated with quinine administration in a high proportion of instances. If quinine is injected... 

G6PD deficiency is expressed clinically by a spectrum of hemolytic syndromes. Clinical... 

The incidence and severity of Salmonellosis is increased in the following conditions or comorbidities. Achlorhydria, pernicious anemia, impaired immune response, HIV infection, malnutrition, chronic steroid administration, frequent administration of antibiotics which affects intestinal flora and lowers resistance of colonization, lymphoproliferative diseases, malignant tumors, schistosomiasis, chronic hemolytic syndromes (sickle cell disease), malaria and inflammatory bowel disease, mainly ulcerative cohtis. 

Juvenile Gout and Hyperuricosuria Due to Chronic Compensated Hemolytic Syndrome... 

In this communication we present the case report of the patient with juvenile gout due to chronic compensated hemolytic syndrome as well as data presently available on the other patients suspected of being similarly affected. 

Ulceration, leg 132 Unconsciousness 370 Unexplained (sudden) childhood death 63, 94, 310, 315-319, 321 Unique face 132 Unstable 111, 112 Uremic hemolytic syndrome 202, 251... 

Hematologic diseases autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, pernicous anemia Kidney disease Goodpasture syndrom, lipoid nephroses, minimal change glomerulonephritis Diseases of the gastrointestinal tract autoimmune chronic active hepatitis, autoimmune atrophic gastritis, Crohn s disease, ulcerative colitis... 

Glomerular diseases (e.g., anti-glomerular basement membrane disease, focal segmental glomerularsclerosis, IgA nephropathy, hemolytic uremic syndrome, systemic lupus erythematosus, Alport s syndrome, amyloidosis, membranous nephropathy, and Goodpasture s syndrome)... 

Hemolytic uremic syndrome Minor hemolysis Massive transfusion Newborn... 

Sickle cell hemolytic transfusion reaction syndrome is a unique problem in SCD patients. Owing to alloimmunization, an acute or delayed transfusion reaction may occur. Delayed reactions typically occur 5 to 20 days after transfusion. Alloantibodies and autoantibodies resulting from previous... 

EHEC are the pathogenic subgroup of Stx-producing E. coli (STEC). Acute hemorrhagic colitis has been associated mainly with the 0157 H7 serotype. This serotype has been responsible for larger outbreaks of infection, has higher rates of complications, and appears to be more pathogenic than non-EHEC STEC strains. The spectrum of disease associated with E. coli 0157 H7 includes bloody diarrhea, which is seen in as many as 95% of patients, nonbloody diarrhea, hemolytic-uremic syndrome (HUS), and thrombotic thrombocytopenic purpura. 

Hemolytic uremic syndrome A syndrome characterized by microangiopathic hemolytic anemia, acute renal failure, and a low platelet count (thrombocytopenia). 

The most important product of the hexose monophosphate pathway is reduced nicotinamide-adenine dinucleotide phosphate (NADPH). Another important function of this pathway is to provide ribose for nucleic acid synthesis. In the red blood cell, NADPH is a major reducing agent and serves as a cofactor in the reduction of oxidized glutathione, thereby protecting the cell against oxidative attack. In the syndromes associated with dysfunction of the hexose monophosphate pathway and glutathione metabolism and synthesis, oxidative denaturation of hemoglobin is the major contributor to the hemolytic process. 

Hereditary triose phosphate isomerase (TPI) deficiency is an autosomal recessive disorder that has the most severe clinical manifestations of the erythroenzy-mopathies, including hemolytic anemia, neurological dysfunction, sudden cardiac death, and increased susceptibility to infection. Since the first description by Schneider et al. (S10), more than 25 unrelated families have been reported (Fll). Cases of decreased TPI activities associated with cat cry syndrome and pancytopenia were reported, whereas the correlation between TPI deficiency and these disorders was not clear. Although the degree of anemia is variable, most patients require blood transfusions. Neurological involvement, such as paraparesis, weakness, and hypotonia, is progressive in most cases. No specific therapy is available for the neuropathic manifestations of the disease, and most severely affected children fail to survive beyond the age of 5 years. 

Pyrimidine 5 -nucleotidase (P5N) deficiency appears to be the third most common cause of hereditary nonspherocytic hemolytic anemia after G6PD and PK deficiencies. To date, more than 42 cases have been reported worldwide (FI 1) since the first report by Valentine et al. (V4). This syndrome is characterized by hemolytic anemia, pronounced basophilic stippling of red blood cells (Fig. 6), and a... 

B13. Beutler, E Scott, S., Bishop, A., Margolis, N Matsumoto, F., and Kuhl, W Red cell aldolase deficiency and hemolytic anemia A new syndrome. Trans. Assoc. Am. Physicians 76,154-166 (1973). 

Escherichia coli 0157 5.5/5416 Hemorrhagic colitis, hemolytic uremic syndrome (HUS) a not infrequent cause of industrial food poisoning... 

Complement factor H and platelet-activating factor acetylhydrolase polymorphisms and hemolytic uremic syndrome due to E. coli 0157... 

Ying L, Katz Y, Schlesinger M et al. Complement factor H gene mutation associated with autosomal recessive-atypical hemolytic uremic syndrome. Am J Hum Genet 1999 65[6] 1538—1546. 

Xu H, Iijima K, Shirakawa T et al. Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli 0157-associated hemolytic uremic syndrome. Am J Kidney Dis 2000 36[1] 42—46. 

In the last 20 years, an increased number of enterohemorrhagic diarrhea outbreaks have been caused by highly virulent E. coli strains. EHEC are capable of causing serious complications such as hemolytic uremic syndrome in children and vascular disease in elderly people. E. coli serotype 0157 H7 has been the primary cause of outbreaks of EHEC, but other serotypes such as 026 and Olll are also a major public health concern. The Center for Disease Control has calculated that E. coli 0157 H7 is responsible for more than 70,000 infections and 60 deaths, and other EHEC strains cause approximately 36,000 illnesses and 30 deaths every year in the USA (Mead et al., 1999). In 1994 E. coli 0157 H7 was legally declared an adulterant in ground beef in the USA (USDA/FSIS Directive 10,010.1, 2004). Since then... 

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