Hazard Evaluation Program

Some key elements of a Materials Hazard Evaluation program are  

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Several individuals assisted the subcommittee by providing information on Naval operations, particularly on the Navy s health hazard evaluation program. We thank Captain David Macys (Office of Naval Research), Captain Lawrence Betts (Navy Environmental Health Center), Commander Victoria Cassano (Navy Environmental Health Center), Captain David Sack (Navy Environmental Health Center), Captain Kenneth Still (Navy Health Research Center s Toxicology Detachment), and James Crawl (Navy Environmental Health Center)... 

As science proceeds, many of our endeavors will be with new materials of increased potency and unusual physiological properties. Undoubtedly the technology necessary to produce these materials will become increasingly complex, and require more creative and informative hazards evaluation programs. 

The beginnings of our hazard evaluation program were fairly low key. For years we had been running a Schiemann reaction which involved the thermolysis of an aromatic diazonium fluorborate salt... 

The hazard evaluation program requires the expertise of a number of different disciplines as well as the coordination and reconciliation of the project schedule with factors such as equipment suitability, personnel, training and effluent considerations. Obviously, to take into account all of the difficulties associated with starting and running an unfamiliar process in addition to examining the potential hazards of the process is a complicated task. The format described here will work for most manufacturing operations. 

The author thanks Dr. Colin F. Coates (Sterling Organics Ltd., U.K.) for his help in developing and implementing our hazard evaluation program. 

The Occupational Safety and Health Act of 1970, which created NIOSH, established three roles for epidemiology as part of the Institute s scientific expertise, the article notes field epidemiology under the Health Hazard Evaluation program epidemiology in large studies across multiple sites and surveillance for job-related disease and injury. 

Maki, A.W. 1979. An analysis of decision criteria in environmental hazard evaluation programs. In K.L. Dickson, A.W. Maki, and J. Cairns, Jr. (Eds.), Analyzing the hazard evaluation program. Proceedings of a Workshop, Waterville Valley, New Hampshire, August 14-18, 1978, American Fisheries Society, Washington, D.C. pp. 83-100. 

American Institute of Chemical Engineers (AIChE) (1995). CHEMPAT A Program to Assist Hazard Evaluation and Management. New York American Institute of Chemical Engineers (Publication Z-1). 

Office of Pesticide Programs, Hazard Evaluation Division,... 

The Mond technique of hazard evaluation is fully explained in the ICI technical manual, ICI (1993)(1), to which reference should be made to implement the method. The calculations are made using a standard form, similar to that used for the Dow index. A computer program is available for use with IBM compatible personal computers. 

Frurip, D. J., E. Freedman, and G. R. Hertel, "A New Release of the ASTM CHET AH Program for Hazard Evaluation Versions for Mainframe and Personal Computer," in Proceedings of the International Symposium on Runaway Reactions, Center for Chemical Process Safety/AIChE, New York, NY (1989). 

The motivation for conducting toxicological tests for pharmaceutical, chemical intermediates and impurities arises from the need to ensure the health of employees by preventing adverse reactions from occupational exposure. Employers thus secondarily minimize the associated potential for work interruption. Programs in place at many larger companies routinely test new drug candidates and/or isolated synthetic intermediates for the purpose of occupational health hazard evaluation. 

The development of a toxicological testing program for occupational health hazard evaluation requires consideration of (1) the compounds to be tested, (2) the stage of drug development at which testing occurs, (3) the specific tests to be conducted, and (4) the means for funding. 

Member companies are required to have programs to manage reactive hazards that address, at a minimum, hazard identification, hazard evaluation, management of change, inherently safer design, and adequate procedures and training. 

Reactive chemical hazard management is one element of an overall process safety program and is emphasized through thermal hazards evaluation. 

A general account of how the CHETAH program may be applied to estimation of chemical hazards in relation to process research and development has been given [10], Progressively enhanced and user-friendly versions of CHETAH, which give an overall hazard assessment and are capable of running on personal computers are available from ASTM [11], Comments critical of the criteria used for hazard evaluation in the 1994 CHETAH program [12] led to amendments and enhancements incorporated in the 1998 Windows version. The pure compound physical properties databank has since been expanded from 400 to 1500 compounds and the... 

HETA-84-213-391-1619, Duluth Community Action Program, Duluth, Minnesota. Hazard Evaluations and Technical Assistance Branch, National Institute of Occupational Safety and Health, U S. Department of Health and Human Services. 

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