Growth factors recombinant

Tissue growth factor, recombinant human platelet-derived growth factor, and a synthetic bone matrix... 

Growth factors Recombinant human, bFGF, Sigma-Aldrich Amino acid L-glutamine, Merck Chemicals... 

Thrombomodulin 1009 Transmembrane glycoprotein of 75-kD molecular weight containing 6 repeated domains homologous with epidermal growth factor Recombinant thrombomodulin Dako 1 50 HIER... 

Here, an overview of biopharmaceutical products thus far approved (within the EU and US at least) is presented. The products have been grouped into nine categories recombinant blood factors, recombinant thrombolytics, recombinant insulins, additional recombinant hormones, recombinant hematopoietic growth factors, recombinant IFNs and ILs, recombinant vaccines, monoclonal and engineered antibodies, and additional biopharmaceuticals (e.g., cell therapy, gene therapy, siRNA). 

Keratinocyte growth factor (recombinant, human) palifermin (Kepivance) 16.3 4.5 IV injection (1.0) Mucositis... 

Direct laser-assisted myocardial revascularization (DMR) is an approved technique in the US, Europe, and parts of Asia to create numerous myocardial channels. This results in the induction of a massive inflammatory reaction, which in turn induces angiogenesis. The other FDA-approved pro-angiogenic therapy is the use of recombinant human platelet-derived growth factor (Regranex) for use in the treatment of diabetic neuropathic foot ulcer s. 

Erythropoietin is a growth factor produced by interstitial cells of the kidney in response to hypoxia. Erythropoietin stimulates haematopoiesis in the bone marrow. Recombinant human erythropoietin is used to treat anemias, e.g. anemia caused by chronic renal failure and anemia in AIDS and cancer patients. 

SCF (recombinant product ancestim) is an early-acting hematopoietic growth factor that stimulates the proliferation of primitive hematopoietic and nonhema-topoietic cells [7]. In vitro, SCF has minimal effect on hematopoietic and nonhematopoietic progenitor cells, but it synergistically increases the activity of other hematopoietic growth factors, such as G-CSF, GM-CSF, and EPO. SCF stimulates the generation of dendritic cells in vitro and mast cells in vivo. 

The use of recombinant hematopoietic growth factors (i.e., the commercially available forms of the native products) has been evaluated in many disorders affecting all types of blood cells. Recombinant human hematopoietic growth factors are identified as rHu. Not all uses discussed have received regulatory approval in all countries. 

When hematopoietic growth factors are used clinically, they can be associated with adverse effects. Very often patients who require hematopoietic growth factors are quite ill with their disease (i.e., cancer or kidney failure) or from their treatment (i.e., chemotherapy) and it is difficult to determine if a recombinant growth factor is responsible for a given side effect. Both rHuG-CSF and rHuGM-CSF are associated with mild-to-moderate... 

The recombinant hematopoietic growth factors have had a significant impact on the treatment of cancer, including prevention of serious infections and anemia. 

Fahrner, R.L., Lester, P.M., Blank, G.S., and Reifsnyder, D. H., Non-flammable preparative reversed-phase liquid chromatography of recombinant human insulin-like growth factor-I, ]. Chromatogr. A, 830, 127, 1999. 

Garke, G., Radtschenko, I., and Anspach, F. B., Continuous-bed chromatography for the analysis and purification of recombinant human fibroblast growth factor, /. Chromatogr. A, 857, 137, 1999. 

Muller, C. and Rinas, U., Renaturation of heterodimeric platelet-derived growth factor from inclusion bodies of recombinant Escherichia coli using size-exclusion chromatography, /. Chromatogr. A, 855, 203, 1999. 

Coco, W.M., Encell, L.P., Levinson, W.E. et al. (2002) Growth factor engineering by degenerate homoduplex gene family recombination. Nature Biotechnology, 20, 1246-1250. 

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