Recombinant human keratinocyte growth factor

Chen, B.L., T. Arakawa, C.F. Morris, W.C. Kenney, C.M. Wells, and C.G. Pitt. 1994. Aggregation pathway of recombinant human keratinocyte growth factor and its stabilization. Pharm Res 11 1581-1587. 

Recombinant human keratinocyte growth factor Heparin (0.5% w/v) Solution -50 fold increased stability at 37°C [21]... 

Chen, B. L., and Arakawa, T. (1996), Stabilization of recombinant human keratinocyte growth factor by osmolytes and salts, /. Pharm. Sci., 85,419 422. 

Recombinant human keratinocyte growth factor (rHuKGF/Palifermin)... 

Burdelya LG, Krivokrysenko VI, Tallant TC et al. (2008) An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320 226 230 Chen L, Brizel DM, Rabbani ZN et al. (2004) The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. Int J Radiat Oncol Biol Phys 60 1520-1529 Cohen EP, Fish BL, and Moulder JE (1997) Successful brief captopril treatment in experimental radiation nephropathy. J Lab Clin Med 129 536-547... 

The expression of recombinant proteins in cells in which they do not naturally occur is termed heterologous protein production (Chapter 3). The first biopharmaceutical produced by genetic engineering to gain marketing approval (in 1982) was recombinant human insulin (tradename Humulin ), produced in E. coli. An example of a more recently approved biopharmaceutical that is produced in E. coli is that of Kepivance, a recombinant keratinocyte growth factor used to treat oral mucositis (Chapter 10). Many additional examples are provided in subsequent chapters. 

Human recombinant keratinocytes growth factor KGF receptor... 

Keratinocyte growth factor (recombinant, human) palifermin (Kepivance) 16.3 4.5 IV injection (1.0) Mucositis... 

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