Recombinant human fibroblast growth factor

Garke, G., Radtschenko, I., and Anspach, F. B., Continuous-bed chromatography for the analysis and purification of recombinant human fibroblast growth factor, /. Chromatogr. A, 857, 137, 1999. 

Chadi, G., Moller, A., Rosen, L., Janson, A.M., Agnati, L.A., Goldstein, M Ogren, S.O., Pettersson, R.F. and Fuxe, K. (1993) Protective actions of human recombinant basic fibroblast growth factor on MPTP-lesioned nigrostriatal dopamine neurons after intraventricular Infusion. Exp. Brain Res. 97 145-158. 

Cuevas, P., Giminez-Gallego, G., Carceller, F., Cuevas, B. and Crespo, A. (1993) Single topical application of human recombinant basic fibroblast growth factor (rbFGF) promotes neovascularization in rat cerebral cortex. Surg. Neurol. 39 380-384. 

Heparin has been used in enzyme purification such as recombinant human mast cell tryptase. The purified enzyme is fully active [12]. Heparin-based affinity chromatography also permitted the isolation of growth factors such as basic fibroblast growth factor (bFGF). The affinity is lower when bFGF is complexed with acidic gelatin [13]. The elution of synthetic TFPI (tissue factor pathway inhibitor) peptidic fragments on immobilized heparin has allowed one to find the peptidic sequence responsible for the TFPI-heparin interaction [14]. 

Clements, D.A., Wang, J.-K., Dionne, C.A. and Goldfarb, M. (1993) Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. Oncogene 8 1311-1316. 

Fiddes, J.C., Hebda, P.A., Hayward, P., Robson, M.C., Abraham, J.A. and Klingbeil, C.K. (1991) Preclinical woundhealing studies with recombinant human basic fibroblast growth factor. Ann. N. K Acad. Sci. 638 316-328. 

Wang, W., Lin, S., Xiao, Y. et al. 2008. Acceleration of diabetic wound healing with chitosan-crosslinked collagen sponge containing recombinant human acidic fibroblast growth factor in healing-impaired STZ... 

Ono, I., Tateshita, T., Takita, H., and Kuboki, Y. Promotion of the osteogenetic activity of recombinant human bone morphogenetic protein by basic fibroblast growth factor. /. Craniofac. Surg. 7 418-425,1996. 

Kawaguchi, H. et al.. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Endocrinology, 135,774,1994. 

Table 7.5 Toxicology studies with recombinant human basic fibroblast growth factor...

Figure 3.10 Mechanical loading capac- factor. bFGF basic fibroblast growth fac-ity vs. osteoinductive capacity of several tor rhBMP, recombinant human bone mor-...

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