Platelet-derived growth factor, recombinant

Direct laser-assisted myocardial revascularization (DMR) is an approved technique in the US, Europe, and parts of Asia to create numerous myocardial channels. This results in the induction of a massive inflammatory reaction, which in turn induces angiogenesis. The other FDA-approved pro-angiogenic therapy is the use of recombinant human platelet-derived growth factor (Regranex) for use in the treatment of diabetic neuropathic foot ulcer s. 

Muller, C. and Rinas, U., Renaturation of heterodimeric platelet-derived growth factor from inclusion bodies of recombinant Escherichia coli using size-exclusion chromatography, /. Chromatogr. A, 855, 203, 1999. 

Becaplermin is a recombinant human platelet derived growth factor . It is used to promote the granulation of diabetic, primarily neuropathic, chronic ulcers. Despite the low absorption and short elimination half-life, use during pregnancy and lactation is advised against. 

C. Hydroquinone inhibits the enzyme tyrosine kinase, which converts tyrosine to melanin. It also damages melanocytes. Becaplermin (A) is a recombinant human platelet-derived growth factor that is useful in enhancing wound healing. Etanercept (B) is a recombinant fusion protein approved for treatment of psoriatic arthritis and rheumatoid arthritis. Botulinum toxin (D) is a purified form of bofu-linum foxin fype A approved for fherapy of blepharospasm and sfrabismus. 

Chemical Class Recombinant human platelet-derived growth factor (rhPDGF-BB)... 

A small number of biopharmaceuticals are delivered by nonparenteral means. Recombinant DNase is given by inhalation aerosol to reduce the viscosity of mucus in the lungs of patients with cystic hbrosis. A platelet-derived growth factor in the form of a gel is administered topically for wound healing. Several hormones and peptides are administered in solution by the intranasal route. A solution of an antisense drug used for the treatment of cytomegalovirus retinitis is injected directly into the eye. 

A. General description Becaplermin, a recombinant human platelet-derived growth factor (rhPDGF-BB), is produced by recombinant DNA technology by insertion of the gene for the B chain of PDGF into the yeast Saccharomyces cerevisiae. 

Becapiermin [FDA US AN INN] Platelet-derived growth factor B, recombinant [CAS]... 

Miller, M.S. Use of topical recombinant human platelet-derived growth factor-BB (becaplermin) in healing of chronic mixed arteriovenous lower extremity diabetic ulcers. J. Foot Ankle Surg. 1999, 38 (3), 227-231. 

Jun N-terminal kinases (JNKl and JNK2) were activated in response to cannabinoid receptor agonists in CHO cells expressing recombinant CBi receptors, and this was mediated through a pathway that included Gi/o, PI3K and Ras (Rueda et al. 2000). In the CHO cells (a fibroblast cell line), the transactivation of platelet-derived growth factor receptor was implicated in the JNK activation mechanism (Rueda et al. 2000). 

A Tran, H Parker, V Levi, M Kunitani. Analysis of recombinant human platelet-derived growth factor by reversed-charge capillary zone electrophoresis. Anal Chem 70 3809-3817, 1998. 

What is a decoy receptor How does the decoy receptor osteoprotegerln block bone resorption Some tumors are characterized by excess production of platelet-derived growth factor (PDGF). How might a recombinant decoy receptor function as a chemotherapeutic agent for such a... 

Nabel EG, Yang Z, Liptay S, San H, Gordon D, Haudenschild CC (1993) Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimal hyperplasia in vivo. J Clin Invest 91 1822-1829... 

The amplification of many other DNA sequences has been carried out by transfection of a cloning vector into a bacterial cell, making it possible to produce quantities of natural proteins that were not previously available, as well as unknown proteins. Green fluorescent protein (see Section 25.19) and its derivatives are produced by recombinant DNA technology. A recombinant human-platelet-derived growth factor (rh-PDGF) becaplermin (Regranex) is used clinically in the treatment of diabetic skin ulcers. 

Direct exposure of rat lung myofibroblasts to urban ambient particles from Mexico City < 10 pm in size elicited upregulation of their platelet-derived growth factor receptor a, and this effect was blocked by recombinant endotoxin neutralising protein and mimicked by lipopolysaccharide, but not vanadium, both constituents present within these samples (Bonner et al. 1998). 

Jin P, Ringertz NR (1990) Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts. J Biol Chem 265 14061-14064 Jin P, Sejersen T, Ringertz NR (1991) Recombinant platelet-derived growth factor-BB stimulates growth and inhibits differentiation of rat L6 myoblasts. J Biol Chem 266 1245-1249... 

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