Growth factors interleukins

Oxidized LDL provokes an inflammatory response mediated by a number of chemoattractants and cytokines (e.g., monocyte colony-stimulating factor, intercellular adhesion molecule, platelet-derived growth factor, transforming growth factors, interleukin-1, interleukin-6). 

Primary isolation of HIV is accomplished by cocultivation of patient PBMCs with uninfected donor PBMCs that have been stimulated with phytohemagglutinin (PHA) and treated with the T cell growth factor interleukin-2. Fresh PHA-stimulated donor PBMCs are added to the culture at weekly intervals growth of virus can be detected in 7-32 days depending on the titer of the virus in the inoculum. 

Cytokines, interleukines and growth factors interleukin fragments Therapeutic proteins produced by recombinant technology receptor binding fragments have been used as targeting moiety... 

Trefoir cytokines Fibroblast growth factors Interleukin-1... 

F4. Ford, R., Tamayo, A., Martin, B., Niu, K., Claypool, K., Cabanillas, F., and Ambrus, J., Jr., Identification of B-cell growth factors (interleukin-14 high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas. Blood 1, 283—293... 

A select group of studies has helped to shed light on the possible physiological mechanisms by which thymic factors control the expression of functional aspects of immunity. Probably the most consistent effect of thymic factors is their ability to induce suppressor T cell activity in various animal models. For example, TF5 has been shown to induce suppressor cell activity in spleen cells of nude mice for both antibody and cytotoxic T cell responses (Marshall et al., 1981 Ahmed et ah, 1978, 1979). Similar effects have been observed with several purified thymic peptides including Ta (Ahmed, 1978, 1979) and thymulin (summarized in Bach, 1983). Other thymic peptides, such as Taj, appear to be more associated with the generation of functional helper T cells. Similar helper inductive effects have also been observed with thymulin in both normal thymocytes and nude mouse spleen cells, which may result from its ability to enhance the production of T cell growth factor (interleukin-2, IL-2) (Palacios et ah, 1982 Palacios 1983). 

E14. Everson, M. P., Eldridge, J. H., and Koopman, W. J. Synergism of interleukin-7 with the thymocyte growth factors interleukin-2, interleukin-6, and tumor necrosis factor alpha in the induction of thymocyte proliferation. Cell Immunol 127, 470-482 (1990). 

H33. Houssiau, F. A., Bukasa, K., Sindii, C. J., Van Damme, J., and Van Snick, J. Elevated levels of the 26K human hybridoma growth factor (interleukin-6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin. Exp. Immunol 71, 320-323... 

Platelet derived growth factor Insulin-like growth factors Epidermal growth factor Transformation growth factor- Fibroblast growth factor Interleukin-1 Endothelin-1 Tumor necrosis factor-a MCP-1 VMAP-1 Selectins ICAM-1 VCAM-1 LFA-1... 

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