Regulatory gene

Ras activates a number of pathways among them is the mitogen-activated protein (MAP) kinases, which transmit signals downstream to other protein kinases and gene regulatory proteins... 

Funahashi A, Morohashi M, Kitano H, Tanimura N. CellDesigner a process diagram editor for gene-regulatory and biochemical networks. BioSilico 2003 1 159-62. 

Lesch, K. P., Bengel, D., Heils, A. etal. (1996). Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-31. 

Therefore, it is anticipated that chronic repression of muscle gene expression does not require chronic regulation by the parasite. Rather, this effect is expected to result from chronic suspension of infected cells in a non-Go/Gi gene regulatory environment. A simple hypothesis derived from known characteristics of skeletal muscle cells is that induction of cell cycle re-entry is sufficient to cause both chronic suspension in G2/M and repression of muscle gene expression. This possibility has implications for the number of regulatory points at which the parasite might influence the host cell and possible methods to screen for those products. 

Intravesical infusion of linear PEI/pDNA polyplexes was evaluated in patients with superficial bladder cancer where intravesical therapy with bacillus Calmette-Guerin had failed [6, 224]. Patients had low grade superficial bladder cancer, which expressed H19. The therapeutic pDNA contains H19 gene regulatory sequences that drive the expression of an intracellular toxin. Escalating doses of 2-20 mg plasmid per intravesical treatment were applied, with responders continuing to receive polyplexes once a month every month for 1 year. The treatment resulted in complete ablation of the marker tumor, without any new tumors in four of the 18 patients (22% overall complete response rate). Eight of the 18 patients (44%) had complete marker tumor ablation or a 50% reduction of the marker lesion. 

Baltazar Aguda, Georghe Craciun and Rengul Cetin-Atalay, Data Sources and Computational Approaches for Generating Models of Gene Regulatory Networks. 

Fur is itself part of the family of gene regulatory proteins throughout many bacterial species. The major subclass is mainly involved, like Fur in E. coli, in the control of iron homeostasis, but it can also function in acid tolerance and protection against oxidative stress. Fur also controls the iron-regulated expression of bacterial virulence determinants. One class of the Fur family, Zur, is involved in the regulation of zinc uptake (see below). 

Fig. 1. The generalized protein-protein interaction network that includes (A) direct protein-protein interactions such as in the signal transduction pathway, (B) enzyme-enzyme relations in the metabolic pathway, and (C) transcription factor-expressed gene product relations in the gene regulatory pathway. The interactions in (B) and (C) are termed indirect protein-protein interactions.

Two gene regulatory proteins control the expression of the lac operon ... 

Phosphorylation of gene regulatory proteins such as CREB to control gene expression, usually over several hours. The typical result is to add more enzyme to the cell. CREB induces the phosphoenolpyruvate carboxykinase (PEPCK) gene. 

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