Regulatory DNA Sequences in the Human EPO Gene

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Subsequent studies on the expression of HIF-la and HIF-ljS mRNA revealed that both Aanseription factor subimits are expressed in all adult and embryonic mouse and human Assues (19,20). HIF-la is absolutely requAed for proper embryonic development since HIF-la mice die around day 9 of gestation (21). Two further members of the PAS Aanseription factor family, HIF-2a and ARNT-2, 

Oxygen-Dependent Prolyl Hydroxylation Determines O2 Lability of HIF-1  

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