Gene Regulatory protein

Ras activates a number of pathways among them is the mitogen-activated protein (MAP) kinases, which transmit signals downstream to other protein kinases and gene regulatory proteins... 

Fur is itself part of the family of gene regulatory proteins throughout many bacterial species. The major subclass is mainly involved, like Fur in E. coli, in the control of iron homeostasis, but it can also function in acid tolerance and protection against oxidative stress. Fur also controls the iron-regulated expression of bacterial virulence determinants. One class of the Fur family, Zur, is involved in the regulation of zinc uptake (see below). 

Two gene regulatory proteins control the expression of the lac operon ... 

Phosphorylation of gene regulatory proteins such as CREB to control gene expression, usually over several hours. The typical result is to add more enzyme to the cell. CREB induces the phosphoenolpyruvate carboxykinase (PEPCK) gene. 

Lue NF, Chasman Dl, Buchman AR et al (1987) Interaction of GAL4 and GAL80 gene regulatory proteins in vitro. Mol Cell Biol 7 3446-3451... 

Raumann, B.E., Brown, M.B. and Sauer, R.T. Major Groove recognition by P-sheets the ribbon-helix-helix-family of gene regulatory proteins (1994) Current Op. Struct. Biol. 4, 36-43... 

Gene regulatory proteins in bacteria were predicted (before their precise structure was known) to interact in the major groove of DNA by a two-site model of binding. Describe the data that showed this model to be correct. 

Poellinger L, Cuthill S, Wihelmsson A. 1991. The dioxin receptor A signal-dependent gene regulatory protein [Abstract 13], Toxicologist 11 27. 

These brief treatments of diverse osmotic effects on DNA are adequate to show that changes in the solute composition of the nucleoplasm and cytoplasm trigger a substantial number of effects on the structure and function of DNA and chromatin. These effects, which may be lethal if not reversed, are paired with regulatory responses that lead to changes in the amounts and activities of a wide range of enzymatic, transport, and gene regulatory proteins,... 

The local folding of small globular domains within gene regulatory proteins is required for sequence-specific... 

McElroy C, Manfredo A, Wendt A, GoUnick P, Foster M. TROSY-NMR studies of the 91kDa TRAP protein reveal allosteric control of a gene regulatory protein by ligand-altered flexibility. J. Mol. Biol. 2002 323 463-473. 

Figure 31.2 Lac repressor-DNA complex. The DNA-binding domain from a gene regulatory protein, the lac repressor, binds to a DNA fragment containing its preferred binding site (referred to as operator DNA) by inserting an a helix into the major groove of operator DNA. Notice that a specific contact forms between an arginine residue of the repressor and a G-C base pair in the binding site. [Drawn from lEFA.pdb,]...

Gene regulatory proteins contain specific structural motifs for interacting with DNA (a) helix-tum-helix, (b) zinc fingers, (c) leucine zipper, and (d) helix-loop-helix. 

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