Regulatory genes, expression

Marcus, R.C., Shimamura, K., Sretavan, D., Lai, E., Rubenstein, J.L.R. and Mason, C.A. (1999) Domains of regulatory gene expression and the developing optic chiasm correspondence with retinal axon paths and candidate signaling cells . Journal of Comparative Neurology, 403, 346-58. 

Transactivation. Protein synthesis is initiated or inhibited by the action of the activated GR on DNA. The use of glucocorticoids leads to antiinflammatory effects by first controlling gene expression, which subsequentiy leads to the synthesis and/or suppression of inflammation regulatory proteins. 

Malim MH, Hauber J, Fenrick R, Cullen BR (1988) Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature 335 181-183... 

Cottesman S (1996) Roles for energy-dependent proteases in regulatory cascades. In Lin ECC, Lynch AS (eds) Regidation of gene expression in Escherichia coli. R.G. Landes Co., Austin, TX, p 503... 

Hormone response elements (for steroids, T3, retinoic acid, peptides, etc) act as—or in conjunction with— enhancers or silencers (Chapter 43). Other processes that enhance or silence gene expression—such as the response to heat shock, heavy metals (Cd and Zn +), and some toxic chemicals (eg, dioxin)—are mediated through specific regulatory elements. Tissue-specific expression of genes (eg, the albumin gene in liver, the hemoglobin gene in reticulocytes) is also mediated by specific DNA sequences. 

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