Gene regulatory analyses

Stougaard, J., Sandal, N.N., Gron, A., Kuhle, A. Marcker, K.A. (1987). 5 Analysis of the soybean leghaemoglobin Lbc3 gene regulatory elements required for promoter activity and organ specificity. The EM BO Journal 6, 3565-9. 

St. Leger, R. J., Frank, D. C., Roberts, D. W., and Staples, R. C. (1992). Molecular cloning and regulatory analysis of the cuticle-degrading-protease structural gene from the entomopathogenic fungus, Metarhizium anisopliae. European Journal of Biochemistry, 204, 991-1001. 

Christensen C, Gupta A, Maranas CD, Albert R. Large-scale inference and graph-theoretical analysis of gene-regulatory networks in B. subtilis. Physica A. 2007 373 796-810. 

Li Z, Li P, Krishnan A, Liu JD (2011) Large-scale dynamic gene regulatory network inference combining differential equation models with local dynamic Bayesian network analysis. Bioinformatics 27 2686-2691. doi 10.1093/ bioinformatics/btr454... 

This neural crest plasticity correlates well with the cis-regulatory analysis of Hox genes, which have identified distinct elements responsible for regulating Hox gene expression in the hindbrain vs. the neural crest (Maconochie et al., 1999). 

Kwan, C.T., Tsang, S.L., Krumlauf, R., Sham, M.H. 2001. Regulatory analysis of the mouse Hoxb3 gene multiple elements work in concert to direct temporal and spatial patterns of expression. Dev. Biol. 232, 176-190. 

Would you be surprised if your analysis of the gene regulatory machinery of a eukaryotic cell indicated that DNA sequences far removed (1 or more kbp) from the site of transcription initiation were involved Explain. 

---