Gene regulatory networks processes

Figure 1 A schematic representation of a gene regulatory network involving modules of molecular classes (shown in boxes) the modules shown are the transcriptional units in the genome (G), primary transcripts (Ro), mature transcripts (R), primary proteins (Po), modified proteins (P), and metabolites (M). The labeled steps shown in black lines are transcription (x), RNA processing (p), translation (a), protein modification (p), metabolic pathways (ti), and genome replication (a). The feedback interactions shown in gray lines are discussed in the text. Filled circles represent either inhibition or activation.

Funahashi A, Morohashi M, Kitano H, Tanimura N. CellDesigner a process diagram editor for gene-regulatory and biochemical networks. BioSilico 2003 1 159-62. 

An investigation of transcriptional regulatory networks in Sacch. cerevisiae is reported in [17]. The authors have determined the association of most of the transcriptional regulators with genes across the genome. They use statistical analysis of the measurements to show the presence of network motifs, and then demonstrate that an automated process can use these motifs to assemble a transcriptional regulatory network. For three review articles in this field, see [18-20]. 

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