Genes neuronal

Induction of Gadd45 Embryonic and Gaddi53 genes neuronal cells... 

Thiele TE, Marsh DJ, Ste Marie L, Bernstein IL, Palmiter RD (1998) Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature 396 366-369 Thiele TE, Koh MT, Pedrazzini T (2002) Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor. J Neurosci 22 RC208 Thorsell A, Rimondini R, Heilig M (2002) Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Neurosci Lett 332 1-4 Timmusk T, Palm K, Metsis M (1993) Multiple promoter direct tissue-specific expression of rat BDNF gene. Neuron 10 475-489... 

Naranjo JR, Mellstrom B, Achaval M, Sassone-Corsi P (1991) Molecular pathways of pain Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene. Neuron 5 607-617. 

Milbrandt, J. (1988) Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron, 1,... 

Borowsky B, Mezey E, Hoffman BJ (1993) Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene. Neuron. 10, 851-863. 

Chen, S., Wang, Q.-L., Nie, Z., Sun, H., Lennon, G., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Zack, D.J. 1997. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron 19, 1017-1030. 

Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V. and Saarma, M. (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10 475-489. 

The body has three different tissue-specific isoforms of NO synthase, each encoded by a different gene neuronal nitric oxide synthase (nNOS, isoform I), inducible nitric oxide synthase (iNOS, isoform II), and endothelial nitric oxide synthase (eNOS, isoform III). nNOS and eNOS are tightly regulated by Ca concentration to produce the small amounts of NO required for its role as a neurotransmitter and hormone. In contrast, iNOS is present in many cells of the immune system and cell types with a similar lineage, such as macrophages and... 

Deitcher D.L.,Ueda A, Stewart B.A., Burgess R.W.,KidokoroY, and Schwarz T.L. 1998. Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin. J. Neurosci. 18 2028-2039. 

To circumvent this problem, vectors that are based on lentiviruses have been developed. In contrast to prototypic retroviruses, lentiviruses do not require cell division for integration. Gene-therapy vectors have been developed from a broad spectrum of lentiviruses including human immunodeficiency vims (HIV), simian and feline immunodeficiency vims as well as visna/maedi vims. The most widely used lentiviral vector system is based on HIV-1. These vectors can efficiently transduce a broad spectrum of dividing and nondividing cells including neurons, hepatocytes, muscle cells, and hematopoietic stem cells [1,2]. 

To study the effect of an increased gene dosage of GR, Reichardt et al. (2000) and van den Brandt et al. (2007) generated rodent models of GR overexpression. These approaches confirmed that GR controls neuronal and immune functions in a dosage-dependent manner. These results highlight the importance of tight control of GR expression in target tissues and may explain... 

Very low-density lipoprotein receptor ( VLDLR) and APOE receptor-2 ( APOER2) are two gene family members with redundant functions. They are expressed in neurons of the developing brain and act as cell... 

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