Sassone-Corsi

DeGroot, R. and Sassone-Corsi, P. Hormonal control of gene expression Multiplicity and versatility of cyclic adenosine 3, 5 -monophosphate-responsive nuclear regulators. Mol. Endocrinol. 8 145-153,1993. 

Foulkes, N. and Sassone-Corsi, P. More is better activators and repressors from the same gene. Cell 68 411-414,1992. 

De Cesare, D., Fimia, G. and Sassone-Corsi, P. Signaling routes to CREM and CREB plasticity in transcriptional activation. Trends Biochem Sci. 7 281-285,1999. 

Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P (2006) Control of AIF-mediated Cell Death by the Functional Interplay of SIRTl and PARP-1 in Response to DNA Damage. Cell Cycle 5... 

Chetmg P, Tanner KG, Cheung WL, Sassone-Corsi P, Denu JM, Allis CD (2000) Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell 5(6) 905-915... 

Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA, Herrera RE (2003) The dynamic mobility of histone HI is regulated by cyclin/CDK phosphorylation. Mol Cell Biol 23(23) 8626-8636 Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P (2002) Mitotic phosphorylation of histone H3 spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol 22(3) 874-885... 

Sassone-Corsi P, Mizzen CA, Cheung P, Crosio C, Monaco L, Jacquot S, Hanauer A, Allis CD (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285(5429) 886-891... 

Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC (1999) The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades MSKl as a potential histone H3/HMG-14 kinase. Embo J 18(17) 4779-4793 Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, Mandel JL, Sassone-Corsi P, Hanauer A (1996) Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature 384(6609) 567-570... 

M. Doi, J. Hirayama, and P. Sassone-Corsi, Circadian regulator CLOCK is a histone acetyltransferase. Cell 125, 497-508 (2006). 

Sassone-Corsi In the experiment you showed it is clear that in all those receptors there is extensive alternative splicing. In an RNAse protection assay, picking the probe is crucial. 

Whitmore D, Foulkes N, Sassone-Corsi P 2000 Light acts directly on organs and cells in culture to set a vertebrate circadian clock. Nature 404 87-91... 

Sassone-Corsi Is the PIAS3 interaction occurring in the right place ... 

Schibler Paolo Sassone-Corsi, you have these cell lines that are light responsive. Does the RNAi work in zebra fish ... 

Sassone-Corsi We are just checking those cells. In zebra fish we are using RNA to try to block the various CRYs that these cells contain. 

Sassone-Corsi That s another possibility. These cells can be really nicely infected by adenovirus-based vectors. We could also try introducing additional signalling molecules that these cells don t normally contain. 

Bunger MK, Wilsbacher LD, Moran SM et al 2000 Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103 1009—1017 Cermakian N, Sassone-Corsi P 2002 Environmental stimulus perception and control of circadian clocks. Curr Opin Neurobiol 12 359—365... 

Travnickova-Bendova Z, Cermakian N, Reppert SM, Sassone-Corsi P 2002 Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/ BMALl activity. Proc Natl Acad Sci USA 99 7728-7733... 

Sassone-Corsi What we don t know is what happens in peripheral oscillators. 

Sassone-Corsi We know that the transplanted SCN doesn t receive normal input from the retina. Is it possible that the transplanted SCN is not communicating with the rest of peripheral tissues in the same way I am not sure that the experiment of Bert van der Horst will teU us whether the transplanted SCN is able to entrain a non-functioning peripheral clock. 

Sassone-Corsi I agree. What we don t know is how much the liver, for example, is affected in the double Cry knockout. 

Sassone-Corsi It is one thing to graft an implant in a mouse where the SCN is still wired normally with the rest of the animal it is quite another to transplant a SCN that is not able to wire itself with the rest of the animal. 

Sassone-Corsi You mentioned that phyB interacts with cry2 in the nuclear speckles. Is there colocalization ... 

Sassone-Corsi Does the position of those speckles change during the cycle ... 

Sassone-Corsi If this is true, we should somehow be able to identify this in the brain. 

This chapter was presented at the symposium by Paolo Sassone-Corsi, to whom correspondence should be addressed. 

Sassone-Corsi 2002). In addition the Perl promoter contains a CREM binding site (Travnickova-Bendova et al 2002). 

What is special about the testis that requires the absence of the circadian clock so pervasive in other tissues The testis has a number of characteristics, which make it quite different from other tissues. The testis contains spermatogenic cells that perform a constant and complex cell differentiation program where reductive cell divisions occur. It may be that the complex pattern of gene expression engendered by the circadian clock leads to unfavourable interactions with the developmental process of paramount importance to the testis. Alternatively, the normal oscillation of clock gene expression may be distorted by other transcriptional regulators or co-activators which are only present in seminiferous tubules (Sassone-Corsi 2002). 

Cermakian N, Whitmore D, Foulkes NS, Sassone-Corsi P 2000 Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. Proc Natl Acad Sci USA 97 4339-4344... 

Cermakian N, Monaco L, Pando MP, Dierich A, Sassone-Corsi P 2001 Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Periodl gene. EMBO J 20 3967-3974... 

Morse D, Cermakian N, Brancorsini S, Parvinen M, Sassone-Corsi P 2003 No circadian rhythms in testis Periodi expression is C/orC-independent and developmentally regulated in the mouse. Mol Endocrinol 17 141-151... 

Pando MP, Pinchak AB, Cermakian N, Sassone-Corsi P 2001 A cell based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock. Proc Natl... 

Pando MP, Morse D, Cermakian N, Sassone-Corsi P 2002 Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell 110 107—117 Plautz JD, Kaneko M, Hall JC, Kay SA 1997 Independent photoreceptive circadian clocks throughout Drosophila. Science 278 1632-1635... 

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