Neuronal gene expression

Cirelli, C., Pompeiano, M. Tononi, G. (1996). Neuronal gene expression in the waking state a role for the locus coeruleus. Science 274, 1211-15. 

AA metabolites and PAF have initially been studied in terms of their roles in the inflammatory response, such as increased vascular permeability and the activation of and infiltration by inflammatory cells. It is now becoming apparent, however, that these bioactive lipids have significant neurobiological actions in ion channel functions, receptors, neurotransmitter release, synaptic plasticity and neuronal gene expression. 

Satterlee, J. S., Ryu, W. S. and Sengupta, P., 2004, The CMK-1 CaMKIand the TAX-4 Cyclic nucleotidegated channel regulate thermosensory neuron gene expression and function in C. elegans, Curr Biol, 14, pp 62-8. 

Here, we review the abnormalities of hippocampal structure and function in schizophrenia and consider how they can give rise to memory deficits and psychotic symptoms. While it is unlikely that the hippocampus is the sole locus of pathology in schizophrenia, there is now compelling evidence that (1) hippocampal volume and shape are abnormal early on in the disease process, (2) specific regions of the hippocampus show alterations of neuronal gene expression, protein expression, and cell number, and (3) cognitive deficits and the experience of psychotic symptoms are linked to abnormalities of hippocampal function. 

West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, Takasu MA, Tao X, Greenberg ME. Calcium regulation of neuronal gene expression. Proc. Natl. Acad. Sci. U.S.A. 2001 98 11024-11031. 

Vincent VA, DeVoss JJ, Ryan HS, Murphy GM Jr (2002) Analysis of neuronal gene expression with laser capture microdissection. J Neurosci Res 69 578-586... 

Johnson, J.A. and Nathanson, N.M. (1994) Differential requirements for p21ras and protein kinase C in the regulation of neuronal gene expression by nerve growth factor and neurokines. 7. Biol. Chem. 269 18856-18863... 

Tboenen, H., Otten, U. and Schwab, M. (1979) Orthograde and retrograde signals for the regulation of neuronal gene expression the peripheral sympathetic nervous system as a model. In F.O. Schmitt and... 

Zhu Y, Antony J et al (2006) CD8-t lymphocyte-mediated injury of dorsal root ganghon neurons during lentiviras infection CD 154-dependent ceU contact neurotoxicity. J Neurosci 26(13) 3396-3403 Zhu Y, Antony JM et al (2007) Didanosine causes sensory neuropathy in an HIV/AIDS animal model impaired mitochondrial and neurotrophic factor gene expression. Brain 130(Pt 8) 2011-2023... 

Ceballos-Picot, I., Nicole, A., Briand, P., Grimber, G., Delacourte, A., Defossez, A., Javoy-Agid, F., Lafon, M., Blouin, J.L. and Sinet, P.M. (1991). Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice animal model of gene dosage effects in Down s syndrome. Brain Res, 552, 198-214. 

Fig. 6.5(a) OR gene expression. M, maternal and P, paternal DNA strands 1 2, chromosomes from neurones with differential cis/trans regulation (M/P) of each DNA strand (from Chess et al., 1998). [ = OR gene locus = suppressed regulatory element]... 

---