Gene Approaches

The candidate gene approach directly tests the association of selected genes with drug response or ADR. The major sources of candidates which code for receptor, enzyme or ADME targets, are obtained through literature surveys. Most pharma-... 

The deafness gene approach has proven fruitful for finding genes important to the auditory system 839 A variety of genes have been identified, including a set of genes that apparently interact with each other in the auditory and visual systems 839... 

The surprise is that genes clearly involved in mechanotransduction have not yet been identified by the deafness-gene approach 839... 

The deafness gene approach has proven fruitful for finding genes important to the auditory system. The... 

The surprise is that genes clearly involved in mechano-transduction have not yet been identified by the deafness-gene approach. Clearly disruption of hair-cell function at many levels can lead to deafness, so it is expected that deafness genes include those involved in inner-ear development, in ion balance in the endolymph, and in structural integrity of hair cells. Examination of deafness genes in zebrafish has been particularly thorough, however, and... 

E. The Candidate Gene Approach for Identifying Risk Genes... 

These studies clearly showed how, by a carefully designed candidate gene approach combined with functional studies, one can gain important insights into not only the functional relevance but also into the possible molecular mechanism of pharmacog-enomic associations. 

Huh JH, Kan BC, Nahm SH, Kim S, Ha KS, Lee MH, Kim BD (2001) A candidate gene approach identified phytoene synthase as the locus for mature fruit color in red pepper Capsicum spp.). Theor Appl Genet 102 524-530... 

In the candidate-gene approach - the most frequently used approach adopted to identify the predisposing or causal genes in the complex and multigenic and multifactorial diseases - genes with a known or proposed function, with the potential to influence the disease phenot)q)e, are investigated for a direct role in disease. In a small number of cases of t)q)e 2 diabetes, candidate-gene studies have identified mutations in. 

Simko, L, Costanzo, C., Haynes, K. G., Christ, B. J., Jones, R. W. (2004a). Linkage disequilibrium mapping of a Verticillium dahliae resistanee quantitative trait locus in tetraploid potato (Solanum tuberosum) through a candidate gene approach. Theoretical and Applied Genetics, 108,2X1-224. 

Introduction Candidate Gene Approach Pathway-Based Approach Genome-Wide Scanning Approach... 

---